Study of the functional role of circulating extracellular vesicles as mediators of inflammation in cellular models of Parkinson`s disease
Objective: To study mechanisms of cellular inflammation and neurodegeneration of EVs derived from patients with PD at different disease stages in cell-based disease models. Background:…Spinocerebellar ataxia type 2 specific microRNAs may have an effect on neurodegeneration.
Objective: 1.Identification of microRNA in whole blood PBMCs of SCA2 patients .2.Target prediction and pathway analysis of spinocerebellar ataxia type 2 identified miRNAs. 3.Validation of…the role of the “unfolded protein response” and the perk pathway in parkinson’s disease: study of genetic polymorphisms
Objective: To study a possible association between polymorphisms of the genes coding for proteins involved in the UPR and the development of PD or PD…Genetic and functional analysis of CCDC88C mutations in patients with Parkinson’s disease.
Objective: To investigate the association between rare deleterious CCDC88C variants and PD. Background: SCA40 is a rare form of spinocerebellar ataxia caused by heterozygous mutations…Silencing of hypoxia-inducible factor 1 alpha provokes a neuroprotective response in a SH-SY5Y model of Parkinson’s Disease.
Objective: Our study aims to delineate the role of HIF1α in a SH-SY5Y model of Parkinson’s disease (PD) Background: Parkinson’s disease (PD) is one of…Profile of miRNA expression in CSF of Parkinson’s disease identifies miR-409-3p regulating the apoptosis of dopamine neurons
Objective: To improve the precise diagnosis of PD at early stage requires more feasible and objective methods. MicroRNA (miRNA) was believed to be a potential…Chlorogenic acid attenuates the MPTP induced apoptosis in Parkinson’s disease mouse model through pAkt signaling pathway
Objective: This study deals to investigate and explore the anti-apoptotic and molecular mechanisms of CGA in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonian mice model. Background: The debilitating…Dysregulated long non-coding RNA in Parkinson’s disease contributes to the apoptosis of dopaminergic neuron
Objective: The study aims to explore the expression profiles of lncRNA of PD patients and its roles to the pathogenesis of PD. Background: The molecular…Neuroprotective effect of Lemon oil on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway
Objective: The objective of current investigation was to decipher e the neuroprotective effect of lemon oil (LO) on PC 12 cell lines by 6-hydroxydopamine (6-OHDA)…Risk of developing the Parkinson’s disease against the background of diabetes mellitus type 2.
Objective: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. Background: Parkinson’s disease is a chronic disorder in which…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.