Predictive Factors for Depression in a Multicentric Parkinson’s Disease Mexican Cohort
Objective: To identify predictive factors for depression in a multicentric Parkinson’s disease (PD) mexican cohort. Background: Depression is a common symptom of PD with a…Perry syndrome: Proposal of international diagnostic criteria and a new disease concept
Objective: To propose international diagnostic criteria for Perry syndrome and a new disease concept. Background: Perry syndrome is a rare autosomal dominant neurodegenerative disease characterised…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…Evaluation of apathy before and after subthalamic nucleus deep brain stimulation therapy in advanced Parkinson’s disease patients
Objective: Deep brain stimulation (DBS) has been approved to relieve the motor symptoms of Parkinson's disease (PD) patients when the optimal pharmachologic treatment is unsatisfactory.…Methylphenidate in Progressive Supranuclear Palsy [PSP] – Old drug, New Indications?
Objective: To evaluate whether Methylphenidate can improve some symptoms of PSP. Background: PSP is a neurodegenerative disorder with limited therapeutic options. Methylphenidate[MPH] , a drug…Microstructural changes in white and grey matter related to apathy, depression and anxiety in de novo Parkinson’s disease patients
Objective: To study microstructural changes in grey and white matter in early drug-naïve Parkinson's disease (PD) patients and correlate these changes with neuropsychological manifestations. Background:…Tractographically defined subthalamic connectivity is associated with apathy in Parkinson’s disease and healthy subjects
Objective: We aimed to study the baseline white matter characteristics of tractographically defined subthalamic connectivity using Diffusion Tensor Imaging in Parkinson's Disease patients and healthy…Microstructural Changes in Normal Appearing White Matter in Parkinson’s Disease (PD) Correlate with Motor, Tremor, and Neuropsychiatric Scores
Objective: To determine if microstructural changes in the normal appearing white matter of PD are associated with clinical manifestations of disease. Background: White matter (WM)…Distinct effects of apathy and dopamine on effort-based decision making in Parkinson’s disease
Objective: To determine if disrupted effort-based decision making (EBDM) underlies the syndrome of apathy in PD, and whether this disruption is modulated by the dopaminergic…Quality of Life in Parkinson’s Disease: Impact of Depression and Apathy
Objective: The aim of this study is to investigate whether depression and apathy are independently related to QoL in patients with PD. Therefore, we performed…
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