Progression of dopaminergic and serotonergic dysfunction related to motor and nonmotor manifestations in apathetic and non-apathetic parkinsonian patients: a 4-year longitudinal double-tracer PET study
Objective: To investigate the progression of dopaminergic and serotonergic dysfunction and their relation to motor and nonmotor impairment in parkinsonian patients with or without apathy,…Disrupted Amplitude of Low-frequency Fluctuations and Causal Connectivity in Parkinson’s Disease with Apathy
Objective: We aimed to explore associated neural substrates changes in Parkinson’s disease (PD) with apathy via amplitude of low-frequency fluctuations (ALFF) and Granger Causality Analysis…Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the raphe nuclei
Objective: To investigate whether apathy is related to serotonin depletion in the raphe nuclei in patients with rapid eye movement sleep behaviour disorder (RBD), a…Depression, apathy, fatigue in Parkinson with or without STN DBS
Objective: To determine the prevalence of depression, evaluate the relationship between depression, apathy and fatigue, and the impact of STN DBS on the same symptoms.…Perry syndrome: Proposal of international diagnostic criteria and a new disease concept
Objective: To propose international diagnostic criteria for Perry syndrome and a new disease concept. Background: Perry syndrome is a rare autosomal dominant neurodegenerative disease characterised…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…Evaluation of apathy before and after subthalamic nucleus deep brain stimulation therapy in advanced Parkinson’s disease patients
Objective: Deep brain stimulation (DBS) has been approved to relieve the motor symptoms of Parkinson's disease (PD) patients when the optimal pharmachologic treatment is unsatisfactory.…Methylphenidate in Progressive Supranuclear Palsy [PSP] – Old drug, New Indications?
Objective: To evaluate whether Methylphenidate can improve some symptoms of PSP. Background: PSP is a neurodegenerative disorder with limited therapeutic options. Methylphenidate[MPH] , a drug…Microstructural changes in white and grey matter related to apathy, depression and anxiety in de novo Parkinson’s disease patients
Objective: To study microstructural changes in grey and white matter in early drug-naïve Parkinson's disease (PD) patients and correlate these changes with neuropsychological manifestations. Background:…Tractographically defined subthalamic connectivity is associated with apathy in Parkinson’s disease and healthy subjects
Objective: We aimed to study the baseline white matter characteristics of tractographically defined subthalamic connectivity using Diffusion Tensor Imaging in Parkinson's Disease patients and healthy…
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