Effects of Motor Subtype Stability on Non-Motor Symptoms in Early Parkinson’s Disease
Objective: To determine the effects of motor subtypes’ stability on non-motor symptoms (NMS) over three years in early Parkinson’s disease (PD). Background: Research have found…Effort-based decision-making and neuropsychiatric symptoms before and after subthalamic nucleus deep brain stimulation in Parkinson’s disease
Objective: Parkinson’s disease patients with apathy and patients in the medication OFF state show reduced reward sensitivity in effort-based decision-making tasks. The effect of subthalamic…Altered nucleus accumbens functional connectivity precedes apathy in Parkinson’s disease
Objective: To investigate whether changes in connectivity between neural regions that are associated with goal-directed behaviour predict future development of apathy in people with Parkinson’s…Apathy and impulsivity co-occur in Huntington’s disease
Objective: To determine whether apathy and impulsivity co-occur in people with Huntington’s disease. Background: Apathy and impulsivity are debilitating behavioural changes which often occur in…Identifying neural biomarkers of motivated behavior in Parkinson’s disease using sensing-capable DBS devices
Objective: To investigate neural correlates of motivated, goal directed behavior within the basal ganglia. Background: Apathy is a common and debilitating complication of Parkinson’s disease…Failure of model-based outcome monitoring in Parkinson’s Disease Apathy
Objective: To investigate the neural basis of apathy in Parkinson’s Disease (PD). Background: Apathy is a debilitating and poorly understood syndrome characterised by a reduction…Apathy correlated with motor and non-symptoms in de-novo patients with Parkinson’s disease
Objective: We aimed to investigate how the severity of apathy affects motor symptom and other non-motor symptoms in patients with de-novo Parkinson’s disease (PD). Background:…Apathy in Parkinson’s disease: Relation to autonomic symptoms
Objective: Our overall goal was to learn whether apathy would be associated with autonomic symptoms in Parkinson’s disease (PD). We examined whether a) PD patients…Apathy, white-matter microstructure, and effort-based decision making in Parkinson’s Disease
Objective: To investigate the influence of reward and effort on behavior in PD patients with and without apathy, using a drift-diffusion model to analyze neuroimage…A randomized clinical trial (RCT) to evaluate the effects of safinamide on apathetic non-demented Parkinson’s disease patients
Objective: To evaluate the safety and effects of add-on safinamide on apathy in patients with Parkinson’s disease (PD). Background: Apathy is highly prevalent and disabling…
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