The influence of gender, associated neurological disorder and motive for polysomnography (PSG) in the manifestations of REM sleep behaviour disorder (RBD)
Objective: To access the interrelation and relative influence of gender, associated neurological disorder and context of referral to PSG on the manifestations of (RBD). Background:…Long-Term Effects of LPS and Alcohol in Rats: A Model of Neuro-Degenerative Disease
Objective: We postulate alterations of the intestinal barrier (or leaky guts) enhances inflammation, as well as the production of alpga (α)-synuclein which has characteristic pathological…Impact of a high-fat diet on the behavior of A53T alpha-Synuclein Parkinson’s disease mice
Objective: The aim of this project was to evaluate high-fat diet (HFD) induced behavioral alterations in the A53T alpha-Synuclein Parkinsons’s disease mouse model. Background: Besides…Alpha-synuclein interacts with BAF complex in nucleus
Objective: This study aims to uncover the prospective partner of αS in nucleus. Background: In neuronal cells, large part of alpha-synuclein (αS) localize at presynaptic…Preclinical efficacy of drugs identified by IBM-Watson for repurposing to treat L-DOPA-induced dyskinesia
Objective: To test the efficacy of 3 drugs predicted by IBM Watson for Drug Discovery (WDD) as having the potential to treat L-DOPA-induced dyskinesia (LID).…Profiling of lipoproteins and associated lipids in serum samples from Idiopathic REM Sleep Behavior Disorder patients to identify biomarkers for Parkinson’s disease
Objective: To perform a lipidomic profile in serum samples from IRBD patients collected before and after their conversion to PD and DLB, in order to…Exosomes from patients with Parkinson’s disease are pathological in mice
Objective: To verify the hypothesis that serum-derived exosomes from patients with Parkinson’s disease (PD) may serve as risk carriers for inter-neuronal risk transmission, eventually resulting…Alpha-synuclein expression and cytokine profile in blood of patients with Lewy body dementias
Objective: To examine alpha-synuclein expression in CD45+ and cytokine levels in blood of patients with dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD). Background:…Microglia as modulators of exosomal alpha-synuclein transmission
Objective: It is highly desirable to make clear the underlying mechanism of exosomes-involved communication in the synucleinopathy pathogenesis. Background: Emerging evidence suggests that exogenous pathogenic…Behavioural aspect of transgenic Drosophila melanogaster as a model of Parkinson’s disease treated by Ropinirole alginate nanocomposite
Objective: To evaluate the behavioural changes in transgenic Drosophila melanogaster as a model of Parkinson’s disease treated by different doses of Ropinirole alginate nanocomposite (RANC).…
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