Generation and characterization of iPSC-derived nigral dopaminergic and pyramidal glutamatergic neurons from patients affected by multiple system atrophy
Objective: The aim of the present study is to generate dopaminergic and pyramidal neurons from iPSCs of MSA patients in order to establish an in…Toward a new biomarker on Parkinson’s disease: Study of alpha synuclein on upper enteric system by endoscopy
Objective: The aim of our study was to investigate the alpha synuclein deposition at the enteric nerve system on patient with Parkinson's disease and provide…Conjugal Parkinson´s disease – Real or chance?
Objective: To describe the occurrence of three cases of conjugal Parkinson´s disease (PD) in a data set of 160 PD patients with a follow up…Hypothalamic alpha-synuclein pathology and its relation to non-motor symptoms and disease progression in Parkinson’s disease
Objective: To assess alpha-synuclein pathology and tyrosine hydroxylase (TH) immunoreactivity as a dopaminergic marker in three hypothalamic nuclei with potential clinical implications (paraventricular, supraoptic and…Alpha-synuclein in gastric and colonic mucosa in Parkinson’s disease: Limited role as a biomarker
Objective: We aimed to investigate the utility of alpha-synuclein (α-SYN) immunoreactivity from gastric and colonic mucosal tissues obtained by routine endoscopy to detect Parkinson's disease…Diverse effects of alpha-synuclein fibrils on various neuron cell lines, using different buffers
Objective: To investigate the neurotoxic properties of alpha-synuclein (α-Syn) aggregation in different buffers including PBS, SBF and Tris on altered cell lines, SHSY5Y, SK-N-MC and…Are inflammatory bowel disease and/or treatment with aminosalicylates protective factors against Parkinson’s disease?
Objective: To analyze the association between aminosalicylate-treated inflammatory bowel disease (IBD-A) and Parkinson´s disease (PD) at population level. Background: According to the dual-hit hypothesis, the…Speed and severity of toxicity induced by pre-formed α-synuclein fibrils in rat brain is enhanced by α-synuclein overexpression
Objective: To develop a physiologically relevant model of PD. Background: Intracerebral injection of pre-formed α-synuclein fibrils has emerged as an interesting tool to induce PD-like…Inhibition of glucosylceramide synthase reduces pathology and improves cognition in synucleinopathy murine models
Objective: We investigated the merits of glucosylceramide synthase (GCS) inhibition as a potential treatment for synucleinopathies. Background: Mutations in GBA, the gene encoding glucocerebrosidase, are…Survival and risk of mortality of synucleinopathies: A 15 years population-based study (1991 – 2005)
Objective: To investigate the survival and mortality of synucleinopathies 15 years of study. Background: Limited data are available to estimate the mortality and the causes…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.