sFIDA: A sensitive diagnostic assay for quantification of α-synuclein aggregates
Objective: Optimizing of our sFIDA (surface-based fluorescence intensity distribution analysis) assay for specific detection and quantification of single α-synuclein aggregates. Background: Parkinson's disease (PD) is…Alpha-synuclein – super-resolution microscopy reveals potential new role of alpha-synuclein at the pre-synapse
Objective: Alpha-synuclein is a major key player in Parkinson's disease, however its physiological function still remains elusive. Using super-resolution microscopy this study aims to analyse…Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease
Objective: The main aim of the present study was to investigate whether behavioral and biochemical differences may occur between male and female old (12-month-old) transgenic…Clinical phenotype of Parkinsonian patients with α-synuclein mutation: Our case report and review of the literature
Objective: To illustrate the case of a 60 years old woman with A53T point mutation derived Parkinson's disease (PD) and to review SNCA mutations phenotype,…Brain metabolic profile changes reflect subtle pathological alterations in different murine models of Parkinson’s disease
Objective: Understanding early, and therefore often subtle, disease processes in Parkinson's disease (PD) is essential for the development of disease modifying cures. But in patients,…The serum response factor SRF protect dopamine (DA) neurons in Parkinson’s disease partially by mediate autophagy through a beclin 1-dependent pathway
Objective: To investigate the level of serum response factor(SRF) in rotenone-induced Parkinson's disease(PD) model and PD patients, and explore the potential protective role and underlying…Lysosomal alterations in peripheral blood mononuclear cells of Parkinson’s disease patients
Objective: To identify potential systemic alterations in CMA and macroautophagy markers, and GBA levels/activity in Peripheral Blood Mononuclear Cells (PBMCs) isolated from PD patients with…Associations between cerebrospinal fluid proteins and cytokines in Parkinson’s disease
Objective: To investigate the relationship between cerebrospinal fluid (CSF) proteins and cytokines, and their correlation with clinical measures in PD. Background: Several studies have investigated…Colonic α-synuclein: A potential diagnostic biomarker in Parkinson’s disease
Objective: To validate detection of α-synuclein pathology in the gastrointestinal (GI) tract as a diagnostic marker of Parkinson's disease (PD). Background: α-synuclein (ASN) deposition in…Reduced lifespan and climbing ability observed in the overexpressing human α-synuclein without heat shock protein CNB115 in Parkinson’s disease drosophila line
Objective: To investigate the neurotoxic role of overexpressing α-synuclein without Heat Shock Protein CNB115 (HSP115) in Parkinson's disease Drosophila line. Background: Parkinson's disease (PD) is…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.