Are we underestimating the dysautonomic burden in GBA related a-synucleinopathies?
Objective: The aim of the present study is to understand the prevalence of dysautonomic symptoms in a cohort of Italian glucocerebrosidase (GBA) mutated patients with…Dissecting the genetic complexity of Parkinson’s disease: a Parkin-GBA study
Objective: In this study, we investigate how the PD risk factor GBA would affect the cellular phenotypes associated with homozygous mutations in Parkin, causing an…A Study of Microglial Metabolism in Neuroinflammation
Objective: Targeting of microglial metabolism may be a potential therapeutic option for diseases such as PD [Parkinson’s Disease] and LBD [Lewy Body Dementia]. To establish…Serum uric acid level as a biomarker in sporadic and familial (p.A53T alpha synuclein carriers) Parkinson’s disease: Longitudinal data from the PPMI study
Objective: To determine whether there are longitudinal differences in serum uric acid level among sporadic Parkinson’s disease (PD) patients, PD patients harboring the p.A53T mutation…Analysis of brain-derived blood exosomes for diagnostics of synucleinopathies
Objective: Here, we aimed to determine if measuring of α-synuclein concentration in these vesicles from oligodendrocytes and neurons can distinguish between patients with MSA or…11C-PBB3 PET in PD: does alpha-synuclein pathology start in axonal terminals?
Objective: To use 11C-PBB3 PET binding to monitor alpha-synuclein (a-syn) pathology in PD subjects in vivo. Background: In previous work we have shown binding of…Methylation status of SNCA gene in patients with Parkinson disease in Russian population
Objective: To study methylation status of SNCA gene in patients with Parkinson disease in Russian population Background: The genetic background of Parkinson disease (PD) has…Automated Immunohistochemical Detection of Skin Depositions of Pathological alpha-Synuclein in Idiopathic REM Sleep Behavior Disorder and Parkinsonism
Objective: The goal of this study was to employ a novel highly sensitive dual-stain immunohistochemical (IHC) assay in the assessment of cutaneous pathological alpha-synuclein (aSyn)…CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
Objective: Activated microglia and increased cytokine levels could precede neurodegeneration in neuro-inflammation in A53T mice, and CXCL12 was found increased in plasma CNS-derived exosomes, which…New Neuropathological Staging System for Lewy Body Disease
Objective: Present the validation of the new proposed novel staging system (NSS) for Lewy body disease and compare it against the previously proposed staging systems. Background:…
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