A Phase 2 Dose Escalation Study of Ampreloxetine (TD-9855), a Norepinephrine Reuptake Inhibitor, Given Once-Daily to Treat Neurogenic Orthostatic Hypotension (nOH) in Subjects with Synucleinopathies
Objective: To assess the acute effects of ampreloxetine on the pressor response, improvement of symptoms and safety in a daily, single, escalating doses. Background: nOH…The effect of ATP13A2/PARK9 levels on a-syn spreading in mice brains
Objective: The purpose of this study is to analyze the effect of ATP13A2/PARK9-mediated a-syn secretion on a-syn spreading in mice. Background: Recent studies with cell…A genome wide pleiotropic approach to identify the genetic architecture of multiple system atrophy and its interaction with Parkinson’s disease
Objective: The aim of this study is to provide new insights into the genetic architecture of multiple system atrophy (MSA) and investigate shared molecular genetic…Neuromodulatory potentials of revasterol and Carpogon capitatus Roxb on the rat brain: Novel approach for Parkinson’s diseases
Objective: The aim of the current study is to explore the synergistic effects of revasterol and Carpogon capitatus extract Roxb in rotenone induced rat model…Skin could be the new peripheral tissue of interest in Parkinson’s disease transcriptomics
Objective: Profiling gene expression changes in peripheral tissues in PD. Background: Obtaining tissue for gene expression analysis in PD from CNS is done post mortem.…Oligomeric Alpha-synuclein in Erythrocyte Membrane in Early Parkinson’s Disease
Objective: To determine whether α-synuclein concentrations in the cell membrane and cytoplasm of erythrocytes are altered in PD patients and to evaluate their potential role…Investigating the impact of a-synuclein pathology on human embryonic stem cell derived dopaminergic neurons transplanted in an accelerated a-synuclein rat model of Parkinson’s disease
Objective: In this study, we assess how transplanted human embryonic stem cell (hESC) derived dopaminergic (DA) neurons survive, mature, integrate and innervate the host circuitry…Neuroprotective effect of Yerba mate (Ilex paraguariensis) in a Drosophila model of Parkinson ’s disease
Objective: To test the neuroprotective capacity of Yerba Mate (YM) in an in vivo model of Parkinson's disease. Background: Parkinson's disease (PD) is caused by the…Serological analysis of circulating Alpha Synuclein protein levels by Surface Plasmon Resonance (SPR) In Parkinson’s disease
Objective: α-synuclein (α-Syn) is a presynaptic protein whose overexpression or misfolding contributes to the pathophysiology of Parkinson’s disease (PD). This study aims to estimate the…Widespread distribution and abundant accumulation of alpha-synuclein oligomers in multiple system atrophy brain
Objective: To examine the distribution of alpha-synuclein (αSyn) oligomers as an early pathological change in multiple system atrophy (MSA) brains. Background: Although severe neuronal loss…
- « Previous Page
- 1
- …
- 48
- 49
- 50
- 51
- 52
- …
- 70
- Next Page »