MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Alpha-synuclein"

  • 2016 International Congress

    sFIDA: A sensitive diagnostic assay for quantification of α-synuclein aggregates

    T. Bujnicki, C. Zafiu, O. Bannach, D. Willbold (Jülich, Germany)

    Objective: Optimizing of our sFIDA (surface-based fluorescence intensity distribution analysis) assay for specific detection and quantification of single α-synuclein aggregates. Background: Parkinson's disease (PD) is…
  • 2016 International Congress

    Alpha-synuclein – super-resolution microscopy reveals potential new role of alpha-synuclein at the pre-synapse

    J. Lautenschlaeger, F. Stroehl, A. Stephens, C.F. Kaminski, G.S. Kaminski Schierle (Cambridge, United Kingdom)

    Objective: Alpha-synuclein is a major key player in Parkinson's disease, however its physiological function still remains elusive. Using super-resolution microscopy this study aims to analyse…
  • 2016 International Congress

    Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease

    G. Costa, M.J. Sisalli, L. Contu, A. Scorziello, M. Morelli (Cagliari, Italy)

    Objective: The main aim of the present study was to investigate whether behavioral and biochemical differences may occur between male and female old (12-month-old) transgenic…
  • 2016 International Congress

    Clinical phenotype of Parkinsonian patients with α-synuclein mutation: Our case report and review of the literature

    P. Nigro, N. Tambasco, M. Romoli, S. Simoni, E. Sacchini, E. Brahimi, E. Marsili, F. Ripandelli, P. Prontera, P. Calabresi (Perugia, Italy)

    Objective: To illustrate the case of a 60 years old woman with A53T point mutation derived Parkinson's disease (PD) and to review SNCA mutations phenotype,…
  • 2016 International Congress

    Brain metabolic profile changes reflect subtle pathological alterations in different murine models of Parkinson’s disease

    E. Glaab, F. Giesert, C. Jaeger, P. Dirscherl, A. Zimprich, A. Ulusoy, D.A. Di Monte, P. Garcia, R. Balling, W. Wurst, D. Truembach, M. Buttini, D. Vogt-Weisenhorn (Esch-Alzette, Luxembourg)

    Objective: Understanding early, and therefore often subtle, disease processes in Parkinson's disease (PD) is essential for the development of disease modifying cures. But in patients,…
  • 2016 International Congress

    The serum response factor SRF protect dopamine (DA) neurons in Parkinson’s disease partially by mediate autophagy through a beclin 1-dependent pathway

    X. Cheng (Suzhou, People's Republic of China)

    Objective: To investigate the level of serum response factor(SRF) in rotenone-induced Parkinson's disease(PD) model and PD patients, and explore the potential protective role and underlying…
  • 2016 International Congress

    Lysosomal alterations in peripheral blood mononuclear cells of Parkinson’s disease patients

    N. Papagiannakis, M. Xilouri, C. Koros, M. Stamelou, R. Antonelou, M. Maniati, D. Papadimitriou, M. Moraitou, H. Michelakakis, L. Stefanis (Chaidari, Greece)

    Objective: To identify potential systemic alterations in CMA and macroautophagy markers, and GBA levels/activity in Peripheral Blood Mononuclear Cells (PBMCs) isolated from PD patients with…
  • 2016 International Congress

    Associations between cerebrospinal fluid proteins and cytokines in Parkinson’s disease

    R. Wijeyekoon, S. Moore, K. Farrell, D. Breen, R. Barker, C.H. Williams-Gray (Cambridge, United Kingdom)

    Objective: To investigate the relationship between cerebrospinal fluid (CSF) proteins and cytokines, and their correlation with clinical measures in PD. Background: Several studies have investigated…
  • 2016 International Congress

    Colonic α-synuclein: A potential diagnostic biomarker in Parkinson’s disease

    C. Ruffmann, I. Poggiolini, N. Bengoa-Vergniory, F. Baig, M. Rolinski, J. Klein, M.T. Hu, R. Wade-Martins, J. Alegre-Abarrategui, L. Parkkinen (Oxford, United Kingdom)

    Objective: To validate detection of α-synuclein pathology in the gastrointestinal (GI) tract as a diagnostic marker of Parkinson's disease (PD). Background: α-synuclein (ASN) deposition in…
  • 2016 International Congress

    Reduced lifespan and climbing ability observed in the overexpressing human α-synuclein without heat shock protein CNB115 in Parkinson’s disease drosophila line

    M.S. Islam, H.J. Kim, S.S. Hong (Jeonju, Korea)

    Objective: To investigate the neurotoxic role of overexpressing α-synuclein without Heat Shock Protein CNB115 (HSP115) in Parkinson's disease Drosophila line. Background: Parkinson's disease (PD) is…
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