Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease
Objective: The main aim of the present study was to investigate whether behavioral and biochemical differences may occur between male and female old (12-month-old) transgenic…Clinical phenotype of Parkinsonian patients with α-synuclein mutation: Our case report and review of the literature
Objective: To illustrate the case of a 60 years old woman with A53T point mutation derived Parkinson's disease (PD) and to review SNCA mutations phenotype,…Brain metabolic profile changes reflect subtle pathological alterations in different murine models of Parkinson’s disease
Objective: Understanding early, and therefore often subtle, disease processes in Parkinson's disease (PD) is essential for the development of disease modifying cures. But in patients,…The serum response factor SRF protect dopamine (DA) neurons in Parkinson’s disease partially by mediate autophagy through a beclin 1-dependent pathway
Objective: To investigate the level of serum response factor(SRF) in rotenone-induced Parkinson's disease(PD) model and PD patients, and explore the potential protective role and underlying…Lysosomal alterations in peripheral blood mononuclear cells of Parkinson’s disease patients
Objective: To identify potential systemic alterations in CMA and macroautophagy markers, and GBA levels/activity in Peripheral Blood Mononuclear Cells (PBMCs) isolated from PD patients with…Associations between cerebrospinal fluid proteins and cytokines in Parkinson’s disease
Objective: To investigate the relationship between cerebrospinal fluid (CSF) proteins and cytokines, and their correlation with clinical measures in PD. Background: Several studies have investigated…Colonic α-synuclein: A potential diagnostic biomarker in Parkinson’s disease
Objective: To validate detection of α-synuclein pathology in the gastrointestinal (GI) tract as a diagnostic marker of Parkinson's disease (PD). Background: α-synuclein (ASN) deposition in…Reduced lifespan and climbing ability observed in the overexpressing human α-synuclein without heat shock protein CNB115 in Parkinson’s disease drosophila line
Objective: To investigate the neurotoxic role of overexpressing α-synuclein without Heat Shock Protein CNB115 (HSP115) in Parkinson's disease Drosophila line. Background: Parkinson's disease (PD) is…Histone deacetylase 4 is regulated by microRNA 128 in SH-SY5Y cells of Parkinson’s disease
Objective: To explore the mechanisms and regulating effects of microRNA 128 in Parkinson's disease (PD). Background: PD is the second common progressive neurodegenerative disorder characterized…Autophagic modulation by rosuvastatin prevent rotenone induced neurotoxicity as an in vitro model of Parkinson’s disease
Objective: We investigated effects of statin on autophagy markers and evaluated the neuroprotective effect of rosuvastatin from rotenone induced neurotoxicity. Background: Recently, autophagy pathway is…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.