AAV-mediated human alpha synuclein overexpression in the locus coeruleus (LC) leads to a neuronal loss in the nucleus ambiguus of mouse.
Objective: To investigate the impact and temporal aspects of the neuronal loss in the LC neurons induced by alpha-synucleinopathy Background: In the Braak staging model…Feasibility and Safety of Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: The S4 study aims to characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD)…Development of a prototype alpha-synuclein vaccine to induce T regulatory cells for the treatment of synucleonopathy
Objective: Test the hypothesis that combining humoral and immunosuppressive cellular asyn immunization will enhance asyn clearance, and reduce inflammation and neuropathological symptoms in a human…Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy
Objective: We aimed to develop AAV-based models of MSA Background: Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by a combination of autonomic…Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – a preclinical model of Parkinson’s disease
Objective: In our present study, we developed a new mouse model to study the time dependent effects of cellular A53T-α-synuclein overexpression in the locus coeruleus,…Antisense oligonucleotides containing amido-bridged nucleic acid downregulate SNCA expression and improve motor function in Parkinson’s disease mouse models.
Objective: In this study, we used gapmer-type antisense oligonucleotides (ASOs) containing amido-bridged nucleic acid (AmNA). ASO, short single-stranded stretches of DNA or RNA with complementary…α-Synuclein Preformed Fibrils Induce Disruption of Myelin Basic Protein Expression in Primary Oligodendrocyte Culture; Deciphering Glial Pathology in Multiple System Atrophy
Objective: This research focuses on the impact of extracellular α-synuclein preformed fibrils (α-syn PFFs) on oligodendrocytes (OLGs) as a potential contributor exacerbating the pathology of…Parkinson’s Disease-Like Pathology in the Rat Brain and Colon Following Methamphetamine Self-Administration
Objective: To determine if Parkinson’s disease (PD)-like pathology occurs in brain and colon following termination of methamphetamine (meth) self-administration. Background: Meth abuse increases the risk…Identification of a trehalose treatment regimen with potential to be translated into a therapeutic for the treatment of Parkinson’s disease
Objective: To evaluate the preclinical efficacy of trehalose and to identify a dosing regimen that can be used to clinically evaluate trehalose as a disease-modifying therapy…Comparison of neuropathology in Parkinson’s disease subjects with and without deep brain stimulation
Objective: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the…
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