Bidirectional gut-to-brain and brain-to-gut propagation of α-synuclein pathology in non-human primates
Objective: The prototypic synucleinopathy Parkinson's disease (PD) is hypothesized to spread out from the enteric nervous system (i.e. the gut) via the vagal nerve up…Automated immunohistochemical detection of pathological alpha-synuclein in human tissue biopsy
Objective: The goals of this study were to create a highly sensitive brightfield immunohistochemical (IHC) assay for pathological alpha-synuclein (aSyn) in formalin-fixed, paraffin embedded (FFPE)…α-Synuclein Preformed Fibrils Induce Disruption of Myelin Basic Protein Expression in Primary Oligodendrocyte Culture; Deciphering Glial Pathology in Multiple System Atrophy
Objective: This research focuses on the impact of extracellular α-synuclein preformed fibrils (α-syn PFFs) on oligodendrocytes (OLGs) as a potential contributor exacerbating the pathology of…Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – a preclinical model of Parkinson’s disease
Objective: In our present study, we developed a new mouse model to study the time dependent effects of cellular A53T-α-synuclein overexpression in the locus coeruleus,…Antisense oligonucleotides containing amido-bridged nucleic acid downregulate SNCA expression and improve motor function in Parkinson’s disease mouse models.
Objective: In this study, we used gapmer-type antisense oligonucleotides (ASOs) containing amido-bridged nucleic acid (AmNA). ASO, short single-stranded stretches of DNA or RNA with complementary…Comparison of neuropathology in Parkinson’s disease subjects with and without deep brain stimulation
Objective: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the…Parkinson’s Disease-Like Pathology in the Rat Brain and Colon Following Methamphetamine Self-Administration
Objective: To determine if Parkinson’s disease (PD)-like pathology occurs in brain and colon following termination of methamphetamine (meth) self-administration. Background: Meth abuse increases the risk…Identification of a trehalose treatment regimen with potential to be translated into a therapeutic for the treatment of Parkinson’s disease
Objective: To evaluate the preclinical efficacy of trehalose and to identify a dosing regimen that can be used to clinically evaluate trehalose as a disease-modifying therapy…Evaluation of serum sestrin protein in Parkinson’s disease: a plausible diagnostic marker
Objective: In this study, we evaluated the concentrations of sesn1 and sesn2 in the serum of 50 PD patients and 60 elderly controls. Aging is…Association of CSF biomarkers with motor and non-motor features in moderately advanced Parkinson’s disease cohort: the BioFIND study
Objective: Evaluate associations between CSF biomarkers of neurodegeneration and clinical phenotype in Parkinson’s disease (PD) participants of the BioFIND cohort. Background: Levels of CSF α-synuclein…
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