Elevated serum α-synuclein levels in Huntington’s disease patients
Objective: To investigate serum α-synuclein levels in Huntington’s disease (HD) patients. Background: HD is a heredodegenerative disease caused by mutations in HTT coding for huntingtin…Levels of plasma alpha-synuclein as measured using Single Molecule Array technology is higher in Parkinson’s disease compared to controls and is not influenced by LRRK2 genotype
Objective: To investigate plasma alpha-synuclein levels in PD using ultra-sensitive protein detection technology, and to determine the association of plasma alpha-synuclein with cognitive, motor and…Salivary Alpha-Synuclein a new tool for the diagnosis of Parkinson’s disease?
Objective: The aim of the PARKSYN study was to test the utility of salivary alpha-synuclein (a-syn) concentration in the differential diagnosis between Parkinson's disease (PD)…Pronounced synucleinopathy and nigrostriatal degeneration result in forelimb use deficits in the rat preformed alpha-synuclein fibril model
Objective: Generation of a synucleinopathy model in rats using injections of α-synuclein preformed fibrils (α-syn PFFs) resulting in robust and widespread α-syn pathology and at…Olfactory dysfunction, sleep disturbances, neuronal loss, and regional brain atrophy in an inducible mouse model of Alpha-Synucleinopathy
Objective: The objective of this work is to develop a unique mouse model of spreading α-synucleinopathy to accelerate the development of novel disease-modifying treatments for…Reduced vesicular storage of catacholamines enhance MPTP-induced death of dopaminergic neurons in locus coeruleus and olfactory bulb
Objective: In this study, we employed heterozygous knockout (vmat2+/-) mice to investigate the influence of reduced vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-impaired dopaminergic neurons…Longitudinal alpha-synuclein in cerebrospinal fluid in early Parkinson’s disease, prodromal PD and healthy controls
Objective: To examine the longitudinal relationships between total alpha-synuclein (aSyn) changes in cerebrospinal fluid (CSF), clinical measures, and factors that may influence CSF aSyn in…Total CSF alpha-synuclein is inversely associated with non-motor symptoms in a population of patients with Parkinson’s Disease
Objective: To evaluate the association between PD non-motor symptoms (NMS) and CSF levels of neurodegeneration-related proteins in a population of PD patients, aimed at identifying…Activation of chaperone-mediated autophagy reduces oligomeric alpha-synuclein accumulation in LRRK2(R1441G) knockin mouse model of Parkinson’s disease (PD)
Objective: To determine age-dependent accumulation of oligomeric alpha-synuclein in the brain of aged LRRK2(R1441G) knockin mice; and to explore whether activation of chaperone-mediated autophagy (CMA)…A53T mutant human α-synuclein BAC transgenic mice as a model for Parkinson’s disease
Objective: The aim of this study is to create mouse models reproducing the course of PD pathology and symptoms. Background: Parkinson's disease (PD) is a…
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