Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: To characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD) subjects and compared to…Oral treatment with JNX3001 protects dopaminergic function in a non-human primate model of Parkinson’s disease alpha-synucleinopathy
Objective: We evaluated the efficacy of JNX3001 in an aSyn-based macaque model with plasma exposures associated with efficacy in rodents. Background: Alpha-synuclein (aSyn) deposition is…Investigating the influence of alpha-synuclein promoter (Rep1) polymorphism on cognition, disability and plasma alpha-synuclein levels in Parkinson’s disease
Objective: We sought to investigate the relationship between SNCA Rep1 allele length and cognitive, motor and disability scores in PD, as well with plasma alpha-synuclein…Insulin degrading enzyme, a novel key protein against alpha-synuclein oligomers formation?
Objective: The objective of this work is to study the interaction between α-synuclein and the insulin degrading enzyme in the pancreas of subjects with synucleinopathies.…Elevated serum α-synuclein levels in Huntington’s disease patients
Objective: To investigate serum α-synuclein levels in Huntington’s disease (HD) patients. Background: HD is a heredodegenerative disease caused by mutations in HTT coding for huntingtin…Levels of plasma alpha-synuclein as measured using Single Molecule Array technology is higher in Parkinson’s disease compared to controls and is not influenced by LRRK2 genotype
Objective: To investigate plasma alpha-synuclein levels in PD using ultra-sensitive protein detection technology, and to determine the association of plasma alpha-synuclein with cognitive, motor and…Salivary Alpha-Synuclein a new tool for the diagnosis of Parkinson’s disease?
Objective: The aim of the PARKSYN study was to test the utility of salivary alpha-synuclein (a-syn) concentration in the differential diagnosis between Parkinson's disease (PD)…Pronounced synucleinopathy and nigrostriatal degeneration result in forelimb use deficits in the rat preformed alpha-synuclein fibril model
Objective: Generation of a synucleinopathy model in rats using injections of α-synuclein preformed fibrils (α-syn PFFs) resulting in robust and widespread α-syn pathology and at…Olfactory dysfunction, sleep disturbances, neuronal loss, and regional brain atrophy in an inducible mouse model of Alpha-Synucleinopathy
Objective: The objective of this work is to develop a unique mouse model of spreading α-synucleinopathy to accelerate the development of novel disease-modifying treatments for…Reduced vesicular storage of catacholamines enhance MPTP-induced death of dopaminergic neurons in locus coeruleus and olfactory bulb
Objective: In this study, we employed heterozygous knockout (vmat2+/-) mice to investigate the influence of reduced vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-impaired dopaminergic neurons…
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