Behavioural aspect of transgenic Drosophila melanogaster as a model of Parkinson’s disease treated by Ropinirole alginate nanocomposite
Objective: To evaluate the behavioural changes in transgenic Drosophila melanogaster as a model of Parkinson’s disease treated by different doses of Ropinirole alginate nanocomposite (RANC).…Decreased serum alpha-synuclein in patients with Restless Legs Syndrome and association with SNCA-Rep1 polymorphism
Objective: To investigate whether α -synuclein levels are altered in serum and saliva in patients with RLS and explore influence of the SNCA-Rep1 microsatellite repeat…Impaired lysosomal catabolism of alpha-synuclein in parkinsonian LRRK2(R1441G) mutant mouse embryonic fibroblasts
Objective: Using a unique fluorescence-based flow cytometry assay on LRRK2(R1441G) mutant mouse embryonic fibroblasts (MEFs) to elucidate whether pathogenic LRRK2 mutation affects cellular lysosomal degradation…Alpha-synuclein seeding activity in blood samples from synucleinopathy patients
Objective: Utilize a cell-based assay to determine whether a-syn seeding activity can be amplified and detected from blood components from patients with Parkinson’s disease (PD)…Appendectomy and risk of Parkinson’s disease: A meta-analysis using real-world evidence
Objective: This meta-analysis is aimed to explore the association between appendectomy and Parkinson’s disease (PD) risk. Background: Parkinson’s disease is recently recognized as a systematic…Broad White Matter Impairment in Multiple System Atrophy: A case for Oligodendrocyte Dysfunction
Objective: The main objective of this study was to investigate if there are widespread white matter abnormalities in multiple system atrophy (MSA). Background: MSA differs…Serum cholesterol level is associated with risk of MSA
Objective: We aim to ascertain the association between serum cholesterol and multiple system atrophy (MSA). Background: MSA, a common form of atypical parkinsonism, is a…Natural history of RBD in Parkinson´s disease and response to dopaminergic and non-dopaminergic antiparkinsonian treatment
Objective: To assess the natural history of rapid eye movement sleep behavior disorder (RBD) in patients with Parkinson´s disease (PD) and clarify its response to…PrP as a receptor of alpha-synuclein in the pancreas of patients with synucleinopathies
Objective: We have investigated whether the cellular prion protein interacts with alpha-synuclein in pancreatic cells of patients with synucleinopathies. Background: Neurodegenerative diseases such as Alzheimer’s…Delivery of AAV alpha synuclein to a mouse and rat provides a useful model for the assessment of anti-parkinsonian efficacy of chronic inhibition of LRRK2
Objective: 1. To create an in vivo model system to be used to assess the effect of chronically inhibiting LRRK2 pharmacologically. 2. To confirm previous…
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