First-In-Human Single and Multiple Ascending Dose Trial Design of LY3962681, a Novel Intrathecally Delivered siRNA Targeting α-synuclein mRNA for the Treatment of Patients with Parkinson’s Disease
Objective: Development of a Phase 1 clinical trial evaluating LY3962681, a novel, intrathecally delivered siRNA directly targeting α-synucleinmRNA (SNCA) to reduce α-synuclein protein (ASYN), for the treatment of…Alpha-synuclein affects PRMT5-mediated cytoprotective pathway in neuronally differentiated SH-SY5Y cell
Objective: To explore the impact of α-synuclein (αS) on PRMT5. Background: Alpha-synuclein (αS) is recognized as the pivotal molecule in the pathomechanism of Parkinson's disease.…Structural magnetic resonance imaging patterns reflect α-synuclein propagation in a model of Parkinson’s Disease
Objective: To evaluate structural magnetic resonance imaging (MRI) pattern modifications in an α-synuclein model of Parkinson’s disease (PD). Background: As an early driver of α-synucleinopathies’…String Vessel Formation Regionally Increases in Long Duration Parkinson’s Disease
Objective: Parkinson's disease is a movement disorder characterised by α-synuclein deposition in the form of Lewy bodies and Lewy neurites. Vascular changes have been thought to contribute…Neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in experimental animals of Parkinson disease
Objective: To evaluate neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in rotenone induced mice model of Parkinson disease. Background: Parkinson's…Bright Light Therapy: A Novel Non-Pharmacological Approach to Parkinson’s Disease
Objective: To assess the effectiveness of Bright Light Therapy (BLT) in ameliorating symptoms and neuropathology in an α-synuclein preformed fibril (α-syn PFF) induced Parkinson’s disease…Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s Disease
Objective: To develop a technology capable of ultra-sensitive, in situ amplification of abnormal conformations of αSyn within biological samples, potentially enhancing diagnostic accuracy and shedding…Utilization of Skin Punch Biopsy for the Diagnosis of Alpha-synucleinopathy in Clinical Practice
Objective: To understand the use of skin punch biopsies for diagnosis and management of α-synucleinopathy within a large medical system. Background: Skin punch biopsy has…Exploring the Neuroprotective Potential of Mushroom Extracts in Parkinson’s Disease In-Vitro Models
Objective: This study investigates the potential neuroprotective effects of several mushroom extracts in PD in-vitro models. Background: Parkinson's disease, a progressive condition, involves dysfunction or…TM9SF2 Knockdown Decreases Pathological Alpha-synuclein Aggregation In Vivo
Objective: To determine whether knockdown of transmembrane 9 super family 2 (TM9SF2) decreases the formation of alpha-synuclein inclusions and toxicity to nigral neurons in the…
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