A Patient-Directed AI-Enabled Platform for Continuous Personalised Parkinson’s Management
Objective: To describe the co-design and staged evaluation of a novel AI-enabled digital health platform for Parkinson’s where structured patient and clinician feedback informs iterative…Sex Differences in Motor and Nonmotor Symptoms of De Novo Parkinson Disease by Age Group
Objective: While sex differences in Parkinson's disease (PD) are widely reported, data on how age influences these clinical variations are scarce. It is not fully…Efficacy of Mechanoacoustic Vibration Therapy on Motor Function, Bone Density, and Sleep Architecture in Elderly Women with Restless Legs Syndrome
Objective: To evaluate the rehabilitative impact of targeted mechanoacoustic vibration therapy on mobility, bone mineral density (BMD), pain, and sleep quality in elderly women with…SMR Combined with Multi Omics to Investigate the Mechanism of Action of the Cell Senescence Associated Gene (CDK2AP1) in Parkinson’s Disease
Objective: To identify novel cellular senescence-related genes in PD using multi-omics, determine causal relationships, predict mechanisms, and validate a key candidate in a rat model.…Epigenome-wide and gene-targeted epigenetic profile of isolated REM Sleep Behaviour Disorder: a clinico-molecular study
Objective: Comprehensively characterize the epigenetic profile of isolated REM Sleep Behaviour Disorder (iRBD) using genome-wide and gene-targeted approaches, linking it to clinical measures and phenoconversion.…Role of APOE Polymorphism and CSF Markers of AD Co-Pathology in the Cognitive Trajectories of Sporadic and Genetic Parkinson’s Disease: A Longitudinal Cohort Study
Objective: To evaluate if APOE genotype and CSF biomarkers of AD co-pathology are associated with distinct rates of cognitive decline in PD subtypes. Background: Cognitive…Comparison of clinical symptoms between young-onset and elderly-onset in patient with early Parkinson’s disease
Objective: We compared the clinical symptoms of early Parkinson's disease (PD) between young-onset and elderly-onset. Background: The progression of PD varies depending on the age…Epidemiology of Parkinson’s disease in Southern Brazil: Age- and Sex-Specific Findings from the PROBE-PD Study
Objective: To examine the prevalence of Parkinson’s disease and parkinsonism in individuals aged 60 years and older in a population-based sample from Southern Brazil, analyzing…Planning for the Parkinson’s Pandemic: Care needs in Australian Residential Aged Care Facilities
Objective: To evaluate the prevalence, demographic characteristics and care needs of people with Parkinson’s disease (PD) living permanently in residential aged care facilities (RACF) in…Ecologically Valid, Ambient, Longitudinal, and Unbiased Assessment of Treatment Efficacy in Parkinson’s Disease (EVALUATE-PD)
Objective: To determine the feasibility of using in-home digital biomarkers (DBs) and activity monitoring for clinical trials and studies of early Parkinson’s Disease (PD) and…
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