Cerebrospinal Fluid Markers are associated with Cognitive Decline in GBA1-associated Parkinson’s Disease
Objective: To analyze whether and how cerebrospinal fluid (CSF) amyloid-related markers relate to the longitudinal cognitive profile in PD-GBA1. Background: Cognitive decline in Parkinson’s disease…Cell-type-specific asynchronous aging acceleration across movement disorders
Objective: To quantify brain cell-type–specific biological aging across different movement disorders (MDS) and compare similarities and differences in cellular aging patterns among MDS. Background: It…Digital Speech Biomarkers Reveal Speech Changes in Physiological Aging and Parkinson’s Disease
Objective: This study investigates speech characteristics associated with physiological and pathological aging, using Parkinson’s disease (PD) as a model, with the aim of identifying linguistic…Loss of NAA60-mediated N-terminal acetylation cause primary brain calcification with disturbed Golgi- and phosphate-maintenance functions
Objective: Our ongoing study describes new NAA60-PBC cases, functionally characterizes additional NAA60 protein variants and investigates the cellular mechanisms underlying NAA60-PBC. Background: NAA60 is a…Planning for the Parkinson’s Pandemic: Care needs in Australian Residential Aged Care Facilities
Objective: To evaluate the prevalence, demographic characteristics and care needs of people with Parkinson’s disease (PD) living permanently in residential aged care facilities (RACF) in…Ecologically Valid, Ambient, Longitudinal, and Unbiased Assessment of Treatment Efficacy in Parkinson’s Disease (EVALUATE-PD)
Objective: To determine the feasibility of using in-home digital biomarkers (DBs) and activity monitoring for clinical trials and studies of early Parkinson’s Disease (PD) and…Impact of Innovative Physiotherapy Interventions on Motor Function and Quality of Life in Patients with Parkinson’s Disease and Movement Disorders
Objective: 1. Assess the extent to which innovative physiotherapy interventions improve motor function, as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS).2. Determine the…Breaking Away From the Ivory Tower
Objective: We describe the evolution of the Geriatric Flying Squad (GFS), a rapid response outreach team for residential aged care facilities (RACFs) in the local…A Long-Living Human Tissue Engineered Nigrostriatal Pathway as a Testbed to Study Parkinson’s Disease
Objective: To create a three dimensional (3D) long-living model of human tissue-engineered nigrostriatal pathway (TE-NSP) comprised of discrete somatic and axonal compartments recapitulating the native…Detection and characterization of rare variants in NOTCH2NLC causing false negative molecular diagnosis through long-read sequencing
Objective: This study investigated a NIID patient with typical clinical and imaging features but no detectable NOTCH2NLC GGC expansion using standard testing. Whole-genome long-read sequencing…
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