Neuroprotection and Alleviation of Parkinsonian Phenotypes by Ayurvedic Herbs
Objective: Our laboratory has focused on the herbal treatment of Parkinson’s disease especially by the above two common herbs Withania somnifera (Ws) and Mucuna pruriens…Piperine potentiate the neuroprotective effect of quercetin against MPTP induced neurotoxicity in rats
Objective: (1) Quercetin is well tolerated bioflavonoid used as supplement for various disorders but problem is its low oral bioavailability and (2) Piperine is combined…Study of neuroprotective effects of Ginsenside Rg3 , the prototypal epigenetic Sirtuin-1 activator, in targeting microglia activation and neurotrophic factor (NF) neural plasticity in MPTP model of Parkinson’s disease (PD)
Objective: 1) to examine whether the phyto-neurosteroid: Ginsenoside Rg3 recently demonstrated to activate the epigenetic SIRTI signaling, will rescue the motor impairment in rodent model…eEF1A2 promotes cell survival and protects against MPP+-induced apoptotic neuronal death through the PI3K/Akt/mTOR pathway
Objective: To assess the correlation of eEF1A2 and PI3K/Akt/mTOR expression and investigate the pro-survival role of eEF1A2 in NG108-15 rodent neuroglioma cells. Background: Eukaryotic protein…The therapeutic effect of MANF in the MPTP/MPP+-induced model of Parkinson’s disease
Objective: To observe therapeutic effect of MANF in the attenuation of neurotoxin MPTP/MPP+-induced model of Parkinson's disease Background: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a…Neuroprotective Potency of Tetrahydroisoquinoline a Novel Ayurveda Molecule in Experimental Parkinson’s Disease
Objective: Tetrahydroisoquinoline (TIQ) an identified alkaloid from ancient Indian ‘Ayurveda’ medicine for Parkinson’s disease (PD) was tested for neuroprotection in a cellular system and a…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…Interaction between PLK2 ( Polo-like kinase-2) and alpha-synuclein in the non-human primate MPTP model of Parkinson disease
Objective: The objective is to determine the levels and interactions between PLK2 and one of its main substrates, synuclein, in the non-human primate MPTP model of…Effects of Arachidonyl-2′-chloroethylamide (ACEA), a selective CB1 receptor agonist, in MPTP mouse model of Parkinson’s disease
Objective: Cannabinoids have been demonstrated to be effective in preclinical studies involving oxidative stress, neuroinflammation, and motor complications associated with Parkinson's disease (PD).The CB1 cannabinoid…The regulation of ASIC1a on dopamine release and its implication in the pathogenesis of Parkinson’s disease
Objective: To study the distribution of acid-sensing ion channel 1a (ASIC1a) in dopaminergic neurons and its role in regulating dopamine release, and to explore its…
- « Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- Next Page »