MDS Virtual Congress 2020 » Parkinson's Disease: Molecular Mechanisms of Disease

Meeting: MDS Virtual Congress 2020

A novel peptide reduces α-synuclein levels and neurodegeneration in cell, invertebrate, and mammalian models of Parkinson’s disease

D. O'Hara, S. Nim, K. Hall, M. Kapadia, M. De Snoo, H. Chau, S. Ngana, C. Corbi-Verge, A. Perez-Riba, S. Kalia, L. Kalia, P. Kim (Toronto, ON, Canada)

Alpha-synuclein and Amyloid beta peptide 1-42 in Parkinson’s disease and parkinsonian plus syndrome cohorts

G. Babu, M. Gupta, V. Paliwal (Lucknow, India)

Alpha-synuclein DNA methylation in CD45+ blood cells in Parkinson’s disease

A. Lavrinova, N. Melnikova, A. Dmitriev, I. Miliukhina, E. Litusova, P. Gagarina, O. Berkovich, S. Pchelina, A. Emelyanov (Gatchina, Russian Federation)

Auxilin knockout mice: a model for Parkinsonism with dopamine dysregulation and synucleinopathy

V. DJ, S. Chandra (New Haven, CT, USA)

Cancerous inhibitor of protein phosphatase 2A in Parkinson’s disease

S.J Yin, C. Han, T. Wang (Wuhan, China)

Characterization of Lewy bodies-induced neurodegeneration and synucleopathy in wild-type mice

E. Bezard, L. Zhang, X. Yu, X. Sun, Y. Zhang, G. Ran, S. Dovero, M. Persillet, P. Fernagut, B. Dehay, C. Qin (Beijing, China)

Clinical and Genetic Characteristics of the University of Pennsylvania Parkinson’s Disease Population: Results from the Molecular Integration in Neurological Diagnosis (MIND) Initiative

T. Tropea, N. Amari, N. Han, E. Suh, V. Van Deerlin, A. Chen-Plotkin (Philadephia, PA, USA)

Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field

M. Salvatore, E. Kasanga, K. Lanza, S. Meadows, A. Centner, C. Bishop (Fort Worth, TX, USA)

Detection of alpha-synuclein aggregation from submandibular and esophageal tissue of patients with synucleinopathies

T. Yamasaki, T. Sudhakar, E. Ostrakhovitch, E. Song (Lexington, KY, USA)

Effects of exosomes devised from dopaminergic neurons overexpressing α-synuclein on autophagy and inflammation in microglia

Y. Liang, L. Bu, E. Tao (Guangzhou,Guangdong, China)

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons

F. De Giorgi, F. Laferriere, F. Zinghirino, E. Faggiani, A. Lends, M. Bertoni, X. Yu, A. Gérard, E. Morvan, B. Habenstein, N. Dutheil, E. Doundnikoff, J. Daniel, S. Claverol, C. Qin, A. Loquet, E. Bezard, F. Ichas (Bordeaux, France)

Feasibility of Studying the PD Microbiome in Frozen Saliva and Formalin-Fixed Colon From the Systemic Synuclein Sampling Study (S4)

S. Mosovsky, B. Methe, T. Beach, C. Adler, C. Coffey, T. Foroud, J. Eberling, B. Mollenhauer, L. Chahine (Pittsburgh, PA, USA)

Glucocerebrosidase Deficiency Mediates Propagation of Protein Aggregation via Extracellular Vesicle Dysregulation

K. Jewett, R. Thomas, C. Phan, G. Milstein, S. Yu, L. Pallanck, M. Davis (Seattle, WA, USA)

Gut Microbiota in Parkinson’s disease: influences of device-assisted therapies

M. Lubomski, X. Xu, A. Holmes, J. Yang, R. Davis, C. Sue (Sydney, Australia)

Increased expression of conexin 36 in rodent model of Parkinson disease

M. Viegas, L. Santos, F. Scorza, C. Scorza, A. Rodrigues, A. Almeida (SJD, Brazil)

Intrastriatal injection of alpha-synuclein preformed fibrils results in cognitive dysfunction and L-DOPA reversible sensorimotor impairments in rats

S. Fleming, J. Patterson, L. Yan, C. Kemp, K. Miller, A. Stoll, M. Duffy, D. Herman, J. Lipton, K. Luk, J. Goudreau, C. Sortwell (Rootstown, OH, USA)

Is it time to consider circulating microRNAs as a diagnostic biomarker in REM sleep behavior disorder?

C. Peralta, D. Giardino, A. Garay, J. Fededa, S. Valiensi, V. Barrachina (Buenos Aires, Argentina)

L-DOPA treatment in N2a cells stimulates neuromelanin biosynthesis: Using a novel in vitro model to examine the effect of iron and light on neuromelanin production

S. Martin, V. Jones, J. Taylor, S. Lane, J. Ehlting, A. Helton, P. Walter (Victoria, BC, Canada)

Loss of CHCHD2 and CHCHD10 disrupts mitochondrial cristae phenocopying patient mutations

D. Narendra, Y. Liu, X. Huang, D. Nguyen, M. Shammas, B. Wu, E. Dombi, D. Springer, J. Poulton, S. Sekine (Bethesda, MD, USA)

Male-specific exacerbation of susceptibility to α-synuclein pre-formed fibrils by developmental dieldrin exposure in mice

A. Gezer, J. Kochmanski, S. VanOeveren, A. Cole-Strauss, C. Kemp, J. Patterson, K. Miller, N. Kuhn, D. Herman, A. McIntire, J. Lipton, K. Luk, S. Fleming, C. Sortwell, A. Bernstein (Grand Rapids, MI, USA)

Mass spectrometry-based proteomics brain analysis to distinguish between Parkinson syndromes

A. Rajput, P. Chumala, B. Thompson, A. Rajput, G. Katselis (Saskatoon, SK, Canada)

miRNA sequencing from routine colonic biopsies reveals an enrichment of submucosal hsa-miRNA-486-5p in Parkinson’s disease

A. Kurz, R. Kumar, C. Wenk, B. Nordhoff, J. Schirra, S. Donakonda, G. Höglinger, K. Bötzel, L. Holdt, T. Koeglsperger (Munich, Germany)

Multiplex biomarker discovery for diagnostic and progression markers for Parkinson’s disease with the proximity extension assay technology on inflammation-related analytes

M. Bartl, M. Dakna, S. Schade, B. Otte, C. Trenkwalder, B. Mollenhauer (Göttingen, Germany)

Profile of miRNA expression in CSF of Parkinson’s disease identifies miR-409-3p regulating the apoptosis of dopamine neurons

X.L Tan, J.Q Tan, F.Y Ming, LL. Lv, H.N Zhang, B.S Tang, W.Q Yan, RR. Bai, X.K Peng, Q.L Xiao, C.Y Wang (Changsha, China)

Protective role of astrocytes on α-synuclein accumulation and propagation

T. Tsunemi, Y. Ishiguro, A. Yoroisaka, K. Krainc, N. Hattori (Tokyo, Japan)

Red blood cells alpha-synuclein heteroaggregates in the differential diagnosis of Lewy body dementias, Alzheimer’s disease and healthy controls

G. Palermo, L. Giampietri, S. Daniele, R. Piccarducci, D. Frosini, G. Tognoni, U. Bonuccelli, C. Martini, F. Baldacci, R. Ceravolo (Pisa, Italy)

Rotenone exposure is associated with mitochondrial DNA (mtDNA) damage in humans

S. Goldman, C. Tanner, C. Gonzalez-Hunt, C. Meng, K. Comyns, M. Korell, L. Sanders (San Francisco, CA, USA)

Salivary proteome in Parkinson’s disease

M. Figura, A. Friedman (Warsaw, Poland)

Screening of mutations in PARK2 gene and Dopamine levels in Parkinson’s disease (PD) patients in Coimbatore population, India

I. Iyer, V. Venkatesan, V. Vellingiri (Coimbatore, India)

Sex-related longitudinal change of motor features and biological biomarkers in early Parkinson’s disease from the PPMI cohort

M. Picillo, S. Bressman, C. Coffey, N. Dahodwala, R. Sanders-Pullman, C. Tanner, A. Amara (Salerno, Italy)

The feasibility of detailed phenotyping of muscle mitochondrial respiratory chain function and content in Parkinson’s disease

A. Yarnall, A. Granic, S. Waite, K. Hollingsworth, C. Warren, A. Vincent, G. Gorman, D. Turnbull, R. Taylor, R. Dodds, A. Sayer (Newcastle upon Tyne, United Kingdom)

α-Synuclein propagation via olfactory pathway induces olfactory bulb atrophy and widespread glucose hypometabolism in a non-human primate model

M. Sawamura, H. Onoe, H. Tsukada, K. Isa, N. Uemura, T. Isa, R. Takahashi (Kyoto, Japan)

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