Classification of Parkinson’s disease using AI based on multi-modal brain MRI connectomics
Objective: To develop a novel artificial intelligence (AI) model using connectivity matrices derived from multi-modal brain magnetic resonance imaging (MRI) to aid diagnosis and subtyping…The Effect of Genotype on Voice & Swallowing in Parkinson’s Disease: A Parkinson’s Progression Markers Initiative Study
Objective: The objectives of this project were twofold: 1. Determine how genotypes of Parkinson’s Disease (PD) affect voice & swallowing function, and 2. Examine how…Clinical, Neurophysiological, and Biological Insights into Levodopa-Induced Dyskinesias
Objective: The aim of this study was to determine the clinical, neurophysiological and biological features of Parkinson's Disease (PD) patients with L-Dopa-induced dyskinesias (LIDs). Background:…Beyond Clinical Presentation: Incorporating Neuroimaging and Biofluid Markers to Predict Progression of Parkinson’s Disease
Objective: To assess whether including measurements of neuroimaging and biofluid-based biomarkers improves predictive ability of models of motor and non-motor progression up to 5-year follow-up…One dose fits all? An analysis of the levodopa equivalent dose over time in Parkinson’s disease
Objective: To ascertain and delineate the differences in Levodopa Equivalent Dose (LEDD) among Parkinson’s disease (PD) subtypes and to examine its evolution over the disease’s…Decoding Fatigue in Parkinson’s Disease: Exploring Multifactorial Associations
Objective: To examine the relationship between fatigue, clinical demographics and NMS in PD patients to inform targeted treatment approaches. Background: Non-motor symptoms (NMS) in Parkinson’s…Associations between Choroid Plexus and tau in Parkinson’s Disease
Objective: To investigate the associations between the choroid plexus (ChP) and protein indicators of Parkinson’s Disease (PD). Background: The ChP is the primary organ that…Gathering Prodromal Participant Perspective on Receiving Personal Research Information
Objective: To understand perceptions and expectations of people with prodromal Parkinson’s disease (PD) around receiving personal research information. Background: There is limited information on the…Association between Kinetic Parameters of Alpha-synuclein Seed Amplification Assay in CSF and Parkinson’s Disease Subtypes.
Objective: To assess differences in kinetics parameters of the αSyn seeding amplification assays in CSF (CSF-αSyn-SAA) in Parkinson’s Disease (PD) subtypes based on the presence…LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Pathologic Alpha-Synuclein: Clinical and Biomarker Characterization
Objective: To compare clinical and biomarker features and rate of progression among LRRK2-associated parkinsonism cases with and without in vivo evidence of pathologic alpha-synuclein (asyn)…
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PPMI