Do Lower Doses of Botulinum Neurotoxin Type-A Offer a Longer Duration of Effect and Superior Efficacy in Patients with Cervical Dystonia?
Objective: To determine if there is a difference in efficacy and duration of effect between high-dose and low-dose botulinumtoxin neurotoxin type-A for cervical dystonia. Background:…Rapidly Progressive Pallidopyramidal Syndrome related to Parkin gene mutation
Objective: To describe a case of rapidly progressive Pallidopyramidal syndrome related to Parkin gene mutation. Background: Parkin gene mutations are most commonly found in autosomal…Recrudescence of a Compensated Hemidystonia-hemiatrophy Syndrome After COVID-19 Infection
Objective: To educate readers about a unique presentation of hemidystonia-hemiatrophy syndrome which presented after an infection with COVID-19 Background: Hemidystonia-hemiatrophy syndrome is a rare disorder…Altered [18F]VAT Uptake Supports Cholinergic Dysfunction in Isolated Adult-Onset Cervical Dystonia
Objective: Our aim is to investigate whether altered cholinergic function is associated with isolated adult-onset cervical dystonia (CD). Background: Animal models and clinical observations suggest…Machine Learning-Driven Exploration of Epigenetic Patterns in Huntington’s Disease: Understanding Histone Modification Dynamics
Objective: This study explores histone modifications, an underexplored aspect of HD's epigenetics, aiming to uncover markers influencing disease severity and onset for potential therapeutic targets.…Measuring Cortisol Levels in Persons with Huntington’s Disease
Objective: To assess subjective and objective measures of emotional stress via standardized scales and a physiological measure (salivary cortisol) in persons with Huntington’s Disease (HD)…Mechanism Study of Familial Cortical Myoclonic Tremor with Epilepsy Type 1 Caused by Pentanucleotide Repeat Expansion in the SAMD12 Gene
Objective: This study aims to explore the pathogenic mechanisms of familial cortical myoclonic tremor with epilepsy (FCMTE) using various cellular models, from the perspectives of…Identifying and Managing Spasticity in Neurological Shoulder Dysfunction
Objective: To understand this discrepancy between diagnosis and treatment of spasticity in neurological shoulder dysfunction, we formed an expert panel to establish consensus and provide…Gaps in Diagnosing and Treating Tic Disorders in Latin America: A Survey of Healthcare Workers
Objective: The objective of this study was to investigate the knowledge, treatment, and diagnosis pathways followed for Tic Disorders across Latin America. Background: Tic disorders…Tractography-guided versus Clinical Determination of the Most Effective Contact for Tremor Control in Patients with Deep Brain Stimulation – A Clinical Trial
Objective: To prospectively test the hypothesis whether imaging-guided contact selection based on standardized individual tractography of the dentato-rubro-thalamic tract (DRTT) is non-inferior to clinical contact…
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