Deciphering the Huntington’s Disease Research Landscape: A Comprehensive Bibliometric and Trend Analysis
Objective: To map the Huntington's Disease research landscape, identifying key trends, gaps, and the most impactful studies to guide future research directions and therapeutic strategies.…Disrupted Sleep Circadian Rhythms and Brain Disorders: A Large Prospective Cohort Study
Objective: Disrupted sleep circadian rhythms have been linked to increased risks of dementia and mental health, but their associations with other brain disorders were underestimated.…Social Media Listening Study to Understand the Journey and Unmet Needs of Patients Living With PSS
Objective: To employ social media listening to uncover insights into poststroke spasticity (PSS) patient experiences, unmet needs, and impact on quality of life. Background: PSS…Contribution to Efficacy by Active Metabolites of Suvecaltamide in a Preclinical Rat Model of Essential Tremor
Objective: Present the pharmacokinetic/pharmacodynamic (PK/PD) relationship and contribution to anti-tremor efficacy for suvecaltamide and its active metabolites (JZZ05000034=M01, JZZ05000035=M02) in a harmaline-induced rat model of…Effects of Loading, Tapping Performance, and Ballistic Movements on Postural Tremor Features in Patients with Essential Tremor
Objective: To comprehensively evaluate the effects of loading, tapping performance, and ballistic movements on major tremor features in patients with essential tremor (ET). Background: In…Combining EMG and Simulation-Based Biomarkers to Enhance Parkinson’s Resting Tremor Diagnosis
Objective: To develop a diagnostic tool for Parkinson's Disease (PD) resting tremor using surface Electromyography (sEMG) data and musculoskeletal simulations to identify key biomarkers. Background:…ATP8A2 Mutation in a Tunisian Family : Expanding The Clinical Spectrum
Objective: Our aim was to report the clinical and paraclinical findings from two siblings who presented with a new phenotype of ATP8A2 gene mutation. Background:…A Novel SLC9A1 Mutation Associated with Cerebellar Ataxia and Sensorineural Hearing Loss
Objective: To report a novel genetic mutation in the SLC9A1 gene presenting with childhood onset ataxia and sensorineural hearing loss. Background: Lichtenstein-Knorr syndrome is a…Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease
Objective: Accessible and reliable biomarkers for early diagnosis of PD and iRBD are urgently needed to identify candidate therapeutic targets and to monitor disease progression…LRRK2 and GBA Founder Mutations and their Interactions in Parkinson’s Disease
Objective: To evaluate the symptoms of Parkinson’s disease (PD) and time to diagnosis in single and dual carriers of LRRK2 G2019S and GBA N370S. Background:…
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