Interaction of GCase and ganglioside GM1 in the aggregation of α-Synuclein
Objective: The objective of this work is to investigate the relationship between ganglioside GM1 levels and α-synuclein aggregation in the context of GBA1 mutations. Background:…LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Pathologic Alpha-Synuclein: Clinical and Biomarker Characterization
Objective: To compare clinical and biomarker features and rate of progression among LRRK2-associated parkinsonism cases with and without in vivo evidence of pathologic alpha-synuclein (asyn)…Cross-Omics Clustering Identifies Common Molecular Patterns in Parkinson’s Disease
Objective: Uncover novel molecular signatures to define Parkinson's disease (PD) patients' clusters using multi-omics integration and evaluate clinical and neuroimaging data. Background: PD is a…Key neural tracts involved in tau depositions and neurodegeneration as revealed by multimodal MRI and PET assays in progressive supranuclear palsy
Objective: Our study aimed to elucidate the impact of tau depositions on brain microstructure and macrostructure in progressive supranuclear palsy (PSP). Background: The link between…Value of DaTSPECT in rare movement disorders: neurodegenerative diseases
Objective: To explore the expanding indications of dopamine transporter imaging (DaT Spect) beyond the established indications. Background: DaTSPECT is a well-established method to rule out…Metabolic characteristics of brain network in patients with Parkinson’s disease after Deep brain stimulation
Objective: The purpose of this study is to observe the short-term brain metabolic network characteristics of Parkinson's disease patients after STN DBS treatment through PET-CT…Neural Correlates of Dual Task Touchscreen Performance in Parkinson’s Disease
Objective: To compare task-related brain activity during a touchscreen task in Parkinson’s disease (PD) patients and healthy controls (HC) in single (ST) and dual task…Classification of Parkinson’s disease using AI based on multi-modal brain MRI connectomics
Objective: To develop a novel artificial intelligence (AI) model using connectivity matrices derived from multi-modal brain magnetic resonance imaging (MRI) to aid diagnosis and subtyping…Evaluating the association between cognitive impairment and striatal VMAT2 binding using [18F]AV-133 PET in Parkinson’s disease
Objective: To evaluate the association between cognitive deficits and striatal vesicular monoamine transporter type 2 (VMAT2) binding in participants with Parkinson’s disease (PD) using [18F]AV-133…Serotonergic dysfunction and impulse control disorders in Parkinson’s disease: a double-tracer PET study
Objective: To investigate the dysfunction of the serotonergic system related to impulse control disorders in patients with Parkinson’s disease. Background: Impulse control disorders (ICDs, including…
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