Chronic Sleep Fragmentation Accelerates the Onset of Prodromal Symptoms and Pathology in Parkinson’s Disease Model Mice
Objective: To investigate whether chronic sleep fragmentation accelerates the onset of prodromal symptoms and pathology of Parkinson’s disease (PD) in mice. Background: The prodromal phase…Exercise-induced angiogenesis and midbrain neuroprotection in a mouse model of experimental PD
Objective: The goal of this study is to characterize microvascular changes in the SNpc in response to a neuroprotective bout of exercise. Background: Parkinson’s disease…Single cell transcriptomics of peripheral blood mononuclear cells and associations with clinical outcomes in Parkinson’s disease
Objective: To assess transcriptomics signatures for monocytes and T-cells in different stages of Parkinson’s disease (PD) compared to controls and possible correlations with clinical outcomes.…Distinct Gut Microbiome in Parkinson’s disease Based on the Presence of Premotor Rapid-Eye Movement Sleep Behavior Disorders: Exploring the Alpha-synuclein
Objective: We aim to investigate the microbiome composition and functional profiles in Parkinson’s disease (PD) patients with and without premotor rapid eye movement sleep behavior…Clinical features and brain [18F] FDG PET patterns in patients with progressive supranuclear palsy with and without ventricular dilatation
Objective: To describe the clinical features and the metabolic patterns assessed by the brain [18F] FDG-PET in a cohort of PSP patients with or without…Cortical activity during visually perturbed gait in older adults
Objective: The primary aim of this preliminary study was to explore pre-frontal cortex (PFC) and posterior parietal cortex (PPC) activity in older adults (OAs) during…Early GBA-Related Parkinson’s Disease has a Distinct Clinical Phenotype and Cholinergic Innervation
Objective: This study aims to characterize the clinical features and cholinergic innervation of early Parkinson’s disease (PD) patients with GBA mutations (GBA-PD). Background: The GBA-PD…Habenular Structural Connectivity Changes in Parkinson’s Disease: A 7T MRI Study
Objective: To assess if the structural connectivity of habenula (Hb) differs between Parkinson’s disease (PD) patients and healthy controls (HCs). Background: PD is marked by…Cerebral metabolic network in PLA2G6-associated parkinsonism
Objective: To characterize the cerebral metabolic network in PLA2G6-associated parkinsonism (PLA2G6-P). Background: PLA2G6-associated neurodegeneration is known as a continuum of phenotypes. Patients with late-onset PLA2G6-associated…Longitudinal Structural and Functional Correlates of Progression in Isolated Rapid Eye Movement Sleep Behaviour Disorder
Objective: To identify progressive structural and functional imaging alterations in a longitudinal cohort of patients with isolated rapid eye movement sleep behavior disorder (iRBD). Background:…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.