Clinical characteristics associated with early discontinuation of Levodopa-Carbidopa Intestinal Gel infusion in patients with advanced Parkinson Disease.
Objective: To determine the clinical characteristics associated with early withdrawal of Levodopa-Carbidopa Intestinal Gel infusion (LCIG) in patients with advanced Parkinson´s Disease (APD) Background: LCIG…Evaluating Clinical Practices of General Neurologists and Movement Disorder Specialists Based on 2020 AAN Parkinson Disease Quality Metrics
Objective: To evaluate and compare clinical practices of providers caring for patients with Parkinson’s disease utilizing searchable proxies of published quality metrics. Background: In 2020,…Role of RNA splicing in Parkinson’s disease
Objective: To identify key molecular perturbations affecting medium spiny neuron functions and their role in the clinical symptoms of Parkinson’s disease (PD). Background: The degeneration…Melatonin Modulates NLRP3 Inflammasome Activation through TLR2 to Protect Against Parkinson’s Disease
Objective: This study aims to investigate the impact of MLT on inflammation signaling pathway mediated by TLR2 in α-synuclein (α-syn) overexpressed BV2 cells and PD…Genetic signatures stratify PwP into three subgroups with differing responses in two disease-modifying Phase 3 trials and indicate multiple disease biology pathways to Parkinson’s Disease
Objective: To evaluate if 3 newfound genetic subgroups represent differing aspects of disease biology in PD by determining if subgroup participants have differing responses to…Age and Parkinson’s disease: clinical and biomarkers profiling of younger and older patients
Objective: Given the well-known clinical differences and natural history of Parkinson's disease (PD) according ot patients age, wthis study aims at exploring the different pathophysiological…Cortical and Subcortical Brain Volume Changes in Idiopathic REM Sleep Disorder Subjects at Risk for Parkinson’s Disease
Objective: To quantify cortical and subcortical brain volumes using structural MRI analysis in idiopathic REM sleep behavior disorder (iRBD) subjects at risk for Parkinson`s disease…Frontal atrophy in progressive supranuclear palsy[PSP] -an universal feature along with midbrain atrophy?
Objective: To see if frontal atrophy is a frequent radiologic feature of PSP on MRI imaging . Background: Progressive supranuclear palsy[PSP] is a taupathy that…Identification of Brain Atrophy Subtypes in Prodromal and Overt Synucleinopathies: A Multicenter Study
Objective: To identify unique subtypes of synucleinopathy with distinct spatiotemporal patterns and trajectories of brain atrophy and disease burden. Background: The synucleinopathies manifest as a…Clinical and Brain Morphological Characteristics of Early LRRK2-associated Parkinson Disease
Objective: To investigate the impact of LRRK2 mutation in Parkinson disease (PD) and to explore the preclinical markers of LRRK2 mutation carriers who will develop…
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