Common Genotypes Of Dystonia and Response To DBS; Tertiary Center Experience
Objective: This study aims to evaluate the impact of deep brain stimulation (DBS) on monogenic dystonia. Background: Monogenic dystonia is a heterogenic group of disorders…Abnormal brain iron metabolism influences neural function in isolated laryngeal dystonia
Objective: To investigate iron accumulation as a pathophysiological signature of laryngeal dystonia (LD) and assess the abnormal influence of iron on neural activity within the…Epidemiology of Huntington’s Disease in Latin America: A Systematic Review and Meta-analysis.
Objective: To calculate the pooled prevalence of Huntington's Disease in Latin America. Background: Latin America has played a crucial role in advancing our understanding of…Indentifying Key Features for Predicting Clinical Status in Huntington’s Disease Patients Using Raw Speech Samples: a Lightweight Machine Learning Approach
Objective: This study aims to identify key features relevant for predicting the clinical status of patients with Huntington’s Disease (HD) using machine learning techniques applied…Mapping the Efficacy Landscape: A Network Meta-Analysis of Pharmacological Interventions in Huntington’s Disease
Objective: To evaluate and compare the efficacy of pharmacological interventions for Huntington's Disease through a network meta-analysis, identifying the most effective treatments. Background: Huntington’s Disease…Pitolisant as adjunct therapy for refractory restless legs syndrome
Objective: Determine the efficacy and tolerability of pitolisant for adjunct therapy in patients with refractory restless legs syndrome (RLS) Background: RLS treatments include iron, dopaminergics,…A Review of the Genetic Spectrum of Hereditary Spastic Paraplegias in the Middle East and North Africa Region
Objective: To systematically review existing literature and collect data on Hereditary Spastic Paraplegias(HSP) in the Middle East and North Africa(MENA), aiming to assess the prevalence…How Common is Essential Tremor in Germany? A Real-World Claims Data Analysis
Objective: To estimate the prevalence and incidence of essential tremor (ET) stratified by age and sex, using insurance claims data from a large representative [1,2]…A Phase 2b Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of OnabotulinumtoxinA for the Treatment of Upper Limb Essential Tremor: ELATE Trial
Objective: Here, we present the eligibility criteria and study design of ELATE, a Phase 2b clinical trial evaluating the safety and efficacy of onabotA compared…Genetic Analysis of UK Kindreds with Familial Tremor in The Global Parkinson’s Genetics Progam (GP2)
Objective: To gain a better understanding of the genetic basis of familial tremor syndromes. Background: The genetic basis of tremor is poorly understood and familial…
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