Efficacy and Safety of Amantadine in Parkinson’s Disease with Dyskinesia and Motor Fluctuations: A Systematic Review and Meta-Analysis
Objective: To evaluate the efficacy and safety of oral amantadine (AMA) compared to placebo in the treatment of dyskinesia (DYS) and motor fluctuations (MF) in…Pregnancy in Parkinson’s disease: Five cases
Objective: To report additional cases to the literature of Parkinson’s disease (PD) and pregnant. Background: Pregnancy in PD is a relatively rare occurrence as PD…Levodopa-Entacapone-Carbidopa Intestinal Gel in the treatment of advanced Parkinson’s disease: a two-year experience
Objective: To evaluate the efficacy of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG) in the treatment of patients with advanced Parkinson’s Disease (APD). Background: The continuous enteral infusion…Rora deficiency aggravates dopamine neurons loss via reducing NAD+ level in Parkinson’s disease
Objective: To investigate the mechanism by which retinoic acid-related orphan receptor alpha(RORα) regulates NAD+ levels to dopamine neuronal degeneration in Parkinson’s Disease (PD). Background: PD is an age-related degenerative…Exploring the Therapeutic Target for Lewy Body Disease using gba1 Knock-out Medaka
Objective: This study was performed to explore the therapeutic target for Lewy body disease. Background: Lewy body disease (LBD), including Parkinson's disease and diffuse Lewy…Rationale for LRRK2 inhibition in sporadic Parkinson’s disease and the LUMA trial
Objective: To summarize the rationale for LRRK2 inhibition in sporadic PD patients without LRRK2 mutations, and to describe the current design of the LUMA study,…Declining Lymphocyte Count and Lymphocyte-to-Neutrophil Ratio Following Parkinson’s Disease Diagnosis.
Objective: To replicate previous findings in a diverse East London population, further characterising changes in FBC constituents and evaluating their temporal association with PD diagnosis.…Reaching Kinematics in Movement Disorder Patients Using an Open-Source Computer Vision Technology
Objective: In this study, we compared kinematic parameters of reaching task between SCA12 and healthy control participants using a novel tracking device. Background: Reaching for…Alterations of NAD metabolism in symptomatic and asymptomatic carriers of pathogenic GCH1 variant
Objective: To investigate whether carriers of pathogenic GCH1 variant reveal lower NAD levels in the basal ganglia or the cerebellum compared to variant-free controls. Background:…White matter abnormalities in motor subtypes of Parkinson’s disease
Objective: To evaluate white matter microstructural integrity in Tremor dominant Parkinson’s disease (TDPD) and postural instability and gait disturbance (PIGD) subtypes of PD to ascertain…
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