Alpha-synuclein affects PRMT5-mediated cytoprotective pathway in neuronally differentiated SH-SY5Y cell
Objective: To explore the impact of α-synuclein (αS) on PRMT5. Background: Alpha-synuclein (αS) is recognized as the pivotal molecule in the pathomechanism of Parkinson's disease.…Investigating the pathogenesis of GBA1-associated Parkinson’s disease using GBA1 isogenic iPSC lines
Objective: We aim to explore the pathogenesis of GBA1-associated synucleinopathies and discern the gain- vs. loss-of-function hypotheses by genetically engineering GBA1 in an iPSC line derived…Sphingomyelinase Activity in Patients with Sporadic Parkinson’s Disease
Objective: To measure the sphingomyelinase (ASMase) activity in sporadic PD patients and matched healthy controls and identify any clinical or biological correlation with disease’s severity.To…PARKIN gene replacement by AAV-mediated gene delivery as a therapeutic modality for PARKIN-deficient early-onset familial Parkinson’s disease
Objective: Evaluate PARKIN gene replacement by adeno-associated virus (AAV) vector as a therapeutic modality in relevant disease models of early-onset Parkinson’s Disease (EOPD). Background: Biallelic…Correlating Dysarthria with MRI Findings in Temporal Lobe Glioma: Impact of Steroid Therapy on Cerebral Edema
Objective: Examine the relationship between dysarthria and MRI findings in a patient with left posterior mesial temporal lobe glioma and further evaluate the role of corticosteroid therapy in mitigating associated cerebral…Structural magnetic resonance imaging patterns reflect α-synuclein propagation in a model of Parkinson’s Disease
Objective: To evaluate structural magnetic resonance imaging (MRI) pattern modifications in an α-synuclein model of Parkinson’s disease (PD). Background: As an early driver of α-synucleinopathies’…Resting-State Network Alterations in Patients with Isolated REM Sleep Behavior Disorder and their Association with Clinical Symptoms
Objective: To characterize brain functional connectivity (FC) in patients with isolated REM sleep behavior disorder (iRBD) and its associations with clinical features. Background: Patients with…Synaptic Density Loss in Parkinson’s Disease Independent of Age: Preliminary Findings using [18F]SynVesT-1 PET Tracer
Objective: To determine whether synaptic density differs in the brain of people with Parkinson’s disease and healthy controls using the [18F]-SynVesT-1 PET tracer. Background: The…Comparison of Spontaneous Brain Activity in Distinguishing Parkinsonian Variant of Multiple System Atrophy from Parkinson’s Disease at Early Stage
Objective: The primary objective was to explore distinctions in the fractional amplitude of low-frequency fluctuation (fALFF) indicator among early-stage parkinsonian variant of multiple system atrophy…[18F]PR04.MZ PET CT as a clinical tool in the differential diagnosis of PD and other atypical parkinsonian syndromes in the first 5 years of symptoms
Objective: Investigate if the [18F]PR04.MZ PET CT is a useful tool in the differential diagnosis of PD and atypical parkinsonian syndromes (AP), mainly MSA and…
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