A Phase IIb Double-Blind Placebo-Controlled Randomized Cross-Over Clinical Trial of Sodium Oxybate in Isolated Focal Laryngeal Dystonia
Objective: A phase IIb double-blind, placebo-controlled, cross-over, randomized clinical trial of a single dose of sodium oxybate investigated the efficacy and safety of the drug…Paroxysmal non-kinesigenic dyskinesia: atypical neurological presentation of Lyme neuroborreliosis
Objective: To describe unusaul case of paroxysmal non-kinesigenic dyskinesia due to Lyme neuroborreliosis in a elderly female patient. Background: Nervous system Lyme disease is common…Ataxic-spastic gait: a form of presentation of DYT5/DYT-GCH1
Objective: Describe a case of DYT5/DYT-GCH1 presenting with an ataxic-spastic gait Background: DYT5/DYT-GCH1 is an autosomal dominant disease typically characterized by lower limb dystonia starting…GABA in the Basal Ganglia Tracks Motor Severity and Response to BoNT Treatment in Cervical Dystonia
Objective: Determine if GABA and glutamate levels within sensorimotor network nodes correlate with symptom severity in cervical dystonia (CD) and are altered by botulinum neurotoxin…Validation of the Korean Version of the Huntington’s Disease Quality of Life Battery for Carers
Objective: This study aimed to develop a Korean version of the Huntington's disease (HD) quality of life battery for carers (K-HDQoL-C) to assess disease-related burden…Muscle mass, body fat mass, and nutrition in patients with Huntington´s Disease
Objective: To assess skeletal muscle and fat mass, sarcopenia, and nutritional status in Huntington ́s Disease (HD) patients in different disease stages. Background: HD is…Deciphering the Huntington’s Disease Research Landscape: A Comprehensive Bibliometric and Trend Analysis
Objective: To map the Huntington's Disease research landscape, identifying key trends, gaps, and the most impactful studies to guide future research directions and therapeutic strategies.…Disrupted Sleep Circadian Rhythms and Brain Disorders: A Large Prospective Cohort Study
Objective: Disrupted sleep circadian rhythms have been linked to increased risks of dementia and mental health, but their associations with other brain disorders were underestimated.…Social Media Listening Study to Understand the Journey and Unmet Needs of Patients Living With PSS
Objective: To employ social media listening to uncover insights into poststroke spasticity (PSS) patient experiences, unmet needs, and impact on quality of life. Background: PSS…Contribution to Efficacy by Active Metabolites of Suvecaltamide in a Preclinical Rat Model of Essential Tremor
Objective: Present the pharmacokinetic/pharmacodynamic (PK/PD) relationship and contribution to anti-tremor efficacy for suvecaltamide and its active metabolites (JZZ05000034=M01, JZZ05000035=M02) in a harmaline-induced rat model of…
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