Exploring the Therapeutic Potential of Microglial Modulation in Parkinson’s Disease: A Study on Structural Synaptic Plasticity
Objective: We aim to explore the role of glial cells in Parkinson's disease and assess whether modulating microgliafunction could offer therapeutic benefits. Specifically, we investigate…Eye Blink Rate and Putamen DaTScan Covariation in Parkinson’s Disease
Objective: To examine the relationship between blink rate and DaTScan in Parkinson’s disease. Background: Spontaneous eye-blink rate (BR) is blinking without external triggers. Parkinson's disease…Genetic Variants and Levodopa Response in Parkinson’s Disease: Insights from MAO-B and DAT1 Polymorphisms
Objective: This study aimed to find the association of genetic variations between Parkinson’s disease (PD) patients with and without levodopa-induced dyskinesia (LID). we intended to…Decline in functionality according to WHODAS 2.0 associated with disease progression in people with Parkinson’s disease
Objective: To investigate the decline in functionality according to WHODAS-2.0 from early to intermediate stages of PD. Background: Parkinson's disease (PD) is an incurable and…Lessons from the COVID-19 Lockdown: A Novel Mentorship Program for Young Neurosurgeons, Neurologists and Medical Students
Objective: To propose novel virtual mentorship program as a teaching tool to improve career skills among young Neurosurgeon and Ophthalmologists. Background: COVID‐19 pandemic has caused…Evaluation of Neurotransmitter and Co-transmitter Expression in the Aging Human Locus Coeruleus: Relevance to Neurodegenerative Disorders.
Objective: To analyze the age-associated changes in the neurotransmitter/co-transmitter expression and morphometric profiles of human locus coeruleus (LC) neurons using autopsied human tissues. Background: LC…The Pro-LBD Study Investigating Early Detection, Prognosis, and Biomarkers of Prodromal Lewy Body Diseases
Objective: The Pro-LBD cohort study is a prospective, long-term, clinic-biological cohort study of participants who are stratified by their risk of developing a Lewy body…Hyposmia is Associated with Positive CSF α-Synuclein Seeding in Normal Pressure Hydrocephalus
Objective: To detect α-synuclein (αSyn) pathology and associated clinical characteristics in patients with idiopathic normal pressure hydrocephalus (iNPH) through cerebrospinal fluid (CSF) αSyn seed amplification…Adult Onset Spastic Paraplegia in TUBB4A Leukodystrophy
Objective: Introduction: Leukodystrophies are primarily known as childhood diseases, but recent advances in genetic testing and brain imaging have led to an increase in reports…Clinical and neuroimaging factors associated with survival in Multiple System Atrophy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Multiple System Atrophy (MSA)…
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