IPSC-derived Cortical Neurons from Parkinson’s Patients with VPS35 Mutation show Defects in Synapto- and Neurogenesis
Objective: Investigate whether the Parkinson’s disease (PD) VPS35 D620N mutation leads to synaptic dysfunction in human cortical iPSC-derived neurons. Background: Early presynaptic dysfunction and cortico-striatal…Sexual Dimorphism in Clinical Subtypes, Biomarkers and Disease Progression of Parkinson’s Disease
Objective: To investigate differences in clinical subtypes, biomarkers, and course of progression in Parkinson’s disease (PD) between the two biological sexes. Background: PD is a…A Risk of Thromboembolic Complications In Patients With Parkinson’s Disease
Objective: A small number of reports refer to studies assessing the risk of thromboembolic complications in patients with PD in the form of a stroke,…Evaluation of unsteadiness in patients with dystonia
Objective: To evaluate the cause of unsteadiness in 4 patients with segmental dystonia Background: Mild impairment of postural control has been described in focal and…Benefits of Parkinson’s Team Training Are Maintained Long-Term
Objective: To determine if the improvements in confidence to provide and coordinate patient care and understanding of individual and other team member roles among interprofessional…Behind the Prison Gates – Creating a nurse led Parkinson’s healthcare pathway at HMP Dartmoor Prison, UK.
Objective: To create an equitable Parkinson’s nurse service for people with Parkinson's detained at a Category C, men’s prison in West Devon, UK. Background: There…Device-aided Recording of Gait Parameters and Motor Fluctuations in Patients with advanced Parkinson’s disease in the Home Environment
Objective: To objectively assess mobility and gait parameters in the ON and OFF state in patients with advanced Parkinson's disease (PD) under everyday conditions using…Enhancing iRBD diagnosis through 2D video analysis: a machine learning approach
Objective: Evaluate the performance of a classifier using computer vision trained on video-polysomnography (vPSG) data recorded in the sleep laboratory setting over a single night…TOPAS-MSA: Targeting Oligomer Pathology of Alpha-Synuclein – A Study Evaluating the Safety and Efficacy of Emrusolmin in Patients with Multiple System Atrophy
Objective: The objective of the TOPAS-MSA study is to assess the safety and efficacy of emrusolmin (anle138b/TEV-56286), an orally bioavailable small molecule targeting aggregated α-synuclein,…Prevalence of autonomic symptoms in Multiple System Atrophy on the background of probable RBD
Objective: To discover whether having probable rapid eye movement sleep behavior disorder (RBD) affects prevalence of particular autonomic symptoms, namely falls, constipation and urinary incontinence…
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