A Post Hoc Efficacy Analysis of Phase 3 Trials of Continuous Subcutaneous Foslevodopa/Foscarbidopa in Patients With Parkinson’s Disease
Objective: To further evaluate the efficacy of foslevodopa/foscarbidopa (LDp/CDp), a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs delivered by 24 hour/day customizable continuous subcutaneous infusion, for…LRRK2 inhibition by BIIB122/DNL151 in participants with Pathogenic LRRK2 Variants and Parkinson’s disease: Study Design to Evaluate Safety, Pharmacodynamics and Pharmacokinetics
Objective: To evaluate safety and biomarker effects of BIIB122/DNL151 in participants with pathogenic LRRK2 variants diagnosed with Parkinson’s disease (LRRK2-PD). Background: Increased LRRK2 kinase activity…Parkinson Patients` Motor and Cognitive Functions are Improved by High Intensity LSVT®BIG Physiotherapy – a Randomized Prospective Pilot Trial
Objective: The objective of this pilot study was to evaluate the potential efficacy of high intensity physiotherapy LSVT®BIG on motor and non-motor functions of PD…Neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in experimental animals of Parkinson disease
Objective: To evaluate neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in rotenone induced mice model of Parkinson disease. Background: Parkinson's…Hesperidin lessens rotenone induced Parkinson diseases angiogenesis in nigrostriatal neuronal death through the AMPK/FOXO3 Signaling pathway
Objective: This study is to investigate the neuroprotective effect of HSP in a mouse model of Parkinson's disease (PD) caused by rotenone, with an emphasis…Pre-treatment with Methanolic Extract Mucuna pruriens Seeds Attenuates Serotonin Gene Depletion, Motor Dysfunction and Anxiogenic Responses in a Rat Model of Parkinsonism
Objective: Investigate neuroprotective and genoprotective effects of methanolic Mucuna pruriens (Mp) seed extract in a paraquat-induced Parkinsonism rat model. Background: Paraquat exposure has been linked…Nocturnal Hypertension in Parkinson’s Disease. The Flip Side of a Tainted Coin
Objective: To describe prevalence and severity of nocturnal hypertension and dipping in a cohort of patients with Parkinson’s disease undergoing 24hr blood pressure (BP) monitoring.…Carbidopa does not cause changes in QTc interval even at a supratherapeutic dose
Objective: To assess the cardiac safety of a single supratherapeutic dose of carbidopa in healthy adults. Background: Carbidopa has been approved for use in combination…Palliative Care in Advanced Parkinson’s Disease: Descriptive Analysis and Symptom Impact
Objective: These preliminary study aims to describe the primary clinical features of Parkinson's disease patients requiring palliative care, as assessed by the Edmonton Symptom Assessment…A case of malignant Deep Brain Stimulation Withdrawal Syndrome treated with Opicapone
Objective: We present a case of a patient with Parkinson's disease who developed "malignant Deep Brain Stimulation (DBS) Withdrawal Syndrome" following the removal of the…
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