The effect of intranasal insulin administration on motor and non-motor symptoms in Parkinson’s disease patients; a randomized double-blinded placebo-controlled clinical trial
Objective: To evaluating the effect of intranasal insulin administration on motor and non-motor symptoms in Parkinson’s disease patients; a randomized double-blinded placebo-controlled clinical trial Background:…Apomorphine sublingual film for OFF episodes in PD: Impact on orthostatic hypotension during dose-optimization
Objective: To assess the occurrence of orthostatic hypotension (OH) during apomorphine sublingual film (SL-APO) dose-optimization in patients with Parkinson’s disease (PwPD). Background: SL-APO has been…Reaching the hard-to-reach: the representativeness of patients with parkinsonism recruited to the PRIME-UK cross-sectional study
Objective: To recruit a more representative population of patients with parkinsonism (PwP) focusing on those often excluded from research. Background: PwP who are older, living…Longitudinal brain volume decline in PD with RBD and olfactory dysfunction
Objective: To elucidate longitudinal brain atrophies in PD with or without RBD and anosmia at baseline. Background: REM sleep behavior disorder (RBD) and olfactory dysfunction…Rapid cognitive decline and new-onset psychosis after GPi DBS in a severe GBA mutation carrier: a case demonstrating the importance of genetic screening pre-DBS
Objective: To report the impact of globus pallidus internus (GPi) Deep Brain Stimulation (DBS) on cognition and neuropsychiatric symptoms in a severe glucocerebrosidase (GBA1) mutation…Sex differences for clinicopathological correlations in people with Lewy body pathology
Objective: To determine sex-specific clinical correlations of different Lewy body (LB), Alzheimer’s disease (AD) pathology staging and nigral neuron loss levels in people with LB…Beyond Parkinson´s disease and synucleinopathies: unexpected identification of prodromal corticobasal syndrome by the updated MDS research criteria for prodromal PD
Objective: The aim of the current study was to determine the proportion of patients, initially classified as having prodromal Parkinson’s disease (pPD), phenoconverted to manifest…Adaptive Deep Brain Stimulation for Parkinson’s Disease: from tolerability to patient preference and clinical outcomes
Objective: To characterize patient preference and clinical outcomes in subjects receiving adaptive Deep Brain Stimulation (aDBS) for Parkinson’s Disease (PD). Background: Local field potential (LFP)…Huntingtonism and bilateral basal ganglia hypointensity in a male with an XK variant but no McLeod red cell phenotype
Objective: To report a novel variant of XK without the characteristic RBC phenotype Background: XK disease (previously called McLeod Syndrome) is a rare X-linked disorder…Novel digital marker detects minor hallucinations online at home of patients with Parkinson’s disease
Objective: The aim is to develop a novel implicit and quantitative marker for minor hallucinations (MH) in Parkinson’s disease (PD) for a better tracking of…
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