Increased incidence of Functional movement disorders during COVID-19 pandemic
Objective: To assess the frequency of functional movement disorders (FMD) during the COVID-19 pandemic in comparison to the pre-pandemic period and to identify factors causing…Amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): feasibility in the human
Objective: To assess the feasibility of continuously amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson's disease (PD) patients using a bidirectional, closed-loop brain…Optimizing DBS in PD: Investigating LFP beta power fluctuations in response to chronic stimulation
Objective: To determine if fluctuations in local field potential (LFP) beta power (BP) can be measured over time and whether the degree of fluctuation improves…Human cerebellum contributes to the motor frequency coding for essential tremor and volitional rhythmic movements
Objective: Tremor and volitional rhythmic movement are frequency-specific motions. However, it remains unclear which area of the central nervous system can process frequency information. This…Stop signal reaction time: A promising Diagnostic marker for Functional Cervical Dystonia
Objective: In the current study we explored the clinical utility of Stop Signal Reaction Time (SSRT) as a diagnostic marker for functional cervical dystonia (FCD).…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Habenula Volume in Mood Disorders in Parkinson’s Disease
Objective: To assess whether dysregulation of habenula (Hb) contributes to mood disorders in Parkinson’s disease (PD). Background: PD is often accompanied by mood disorders, such…Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…Development of a health-related quality-of-life (HR-QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: The aim of this project is to develop and validate a health-related quality-of-life (HR-QoL) questionnaire, in a patient and a caregiver version, specific for…15-year effects of initiating treatment for Parkinson’s disease with dopamine agonists or monoamine oxidase B inhibitors compared with levodopa: final results of PD MED early disease randomisation
Objective: PD MED EARLY is a large, pragmatic trial aiming to determine which class of drug as initial treatment provides the most effective long-term control…
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