Sensor-based digital measurement of gait and wrist pronation-supination in clinically-defined classes of Parkinson’s disease progression identified by unsupervised clustering
Objective: To determine how sensor-based measurement of motor performances relate to the heterogeneity of clinical progression in early Parkinson’s disease (PD). Background: Observed disease progression…A 16-week open-label study of the effects of treatment with pimavanserin on activities of daily living in subjects with Parkinson’s disease psychosis (PDP)
Objective: To examine the effects of pimavanserin on activities of daily living during treatment for Parkinson’s Disease psychosis. Background: Accurate assessment of disability associated with…Dopaminergic neuronal cell therapy for Parkinson’s Disease: results from a phase 1 study of Bemdaneprocel
Objective: This first-in-human Phase 1 study aims to assess the safety, tolerability, clinical efficacy, and functional imaging measures of bemdaneprocel in subjects with PD. Background:…Predicting clinical response after Gamma Knife thalamotomy in essential tremor
Objective: To determine clinical, surgical and radiological factors associated with tremor reduction after Gamma Knife thalamotomy (GKT) for essential tremor (ET). Background: GKT is a…Deep brain stimulation for the management of movement disorders in Rett syndrome
Objective: We present two patients with Rett syndrome who underwent deep brain stimulation (DBS) for management of action tremor and rigidity. Video segments of the…Brain-behavior quantification and synchronization to drive closed-loop deep brain stimulation
Objective: Closed-loop DBS systems require a neural biomarker to responsively turn on stimulation, which in turn requires neurophysiological quantification synchronized to behavior or symptoms. Our…Determinants of care partner burden in atypical parkinsonian syndromes
Objective: To understand the determinants of burden among people caring for individuals diagnosed with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), or multiple system atrophy…Sleep hygiene practice in patients with Parkinson’s disease
Objective: We examined the prevalence of diverse sleep hygiene behavior and their associations with insomnia severity in PD patients.We examined the prevalence of diverse sleep…Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Objective: To investigate the association between cerebrospinal (CSF) αS aggregates, MRI, and dopamine transporter spectral tomography (DaTscanTM) imaging metrics. Background: Synuclein amplification assays (SAA) enables…Effect of intensive Game-based neurorehabilitation (GBNR) on gait, balance and quality of life (QOL) in Parkinson’s patients: A prospective randomized control study
Objective: To assess changes in the gait, balance and QOL in PD patients subjected to intensive GBNR in comparison with conventional Neurorehabilitation (NR) therapy using…
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