Disease progression of spinocerebellar ataxia types 1, 2, 3, and 6 before and after ataxia onset: a joint analysis of two longitudinal cohort studies
Objective: The aim was to model the evolution of ataxia and neurological symptoms in SCA1, SCA2, SCA3, and SCA6 over the entire disease span and…Application of multi-parametric diffusion MRI in detecting visual disturbances in advanced Parkinson’s disease population
Objective: We aimed to identify differences in multi-parametric diffusion indices (DTI, NODDI, and DKI) between Parkinson’s disease patients with visual disturbances and those without. Background:…Autosomal dominant Parkinson’s disease caused by SNCA p.E46K variant in family with Russian ancestry: A case report
Objective: To report a family with autosomal dominant Parkinson’s disease (PD) with SNCA p.E46K variant. Background: Alpha-synuclein, encoded by SNCA, is a part of Lewy…Clebopride-induced Rabbit Syndrome: A Case Report.
Objective: This report aims to present a case of rabbit syndrome attributed to clebopride and to highlight the importance of considering nonneuroleptic drugs as a…Trends in the evaluation and management of constipation in patients with Parkinson disease
Objective: Explore common evaluation and management strategies for constipation in patients with Parkinson disease (PD) at a tertiary center. Background: PD is diagnosed based on…The diagnosis value of dopaminergic responsiveness of Parkinson’s disease： a systematic review and meta-analysis
Objective: aimed to confirm the diagnostic value/accuracy of levodopa and/or apomorphine challenge test in parkinsonian syndromes (PDS) to assess their value in the diagnosis of…Case report on heterozygous OPA3 gene mutation causing ataxia
Objective: To describe a case of adult-onset ataxia with a heterozygous p.Lys10Asn OPA3 mutation. Background: Mutations in the OPA3 gene, which encodes a mitochondrial membrane…Asymmetric and profound nigrostriatal dopaminergic dysfunction in Parkinson’s disease with preceding REM sleep behavior disorders
Objective: To investigate the differences in the pattern of nigrostriatal and pontine monoaminergic degeneration patients with de novo Parkinson's disease (PD), stratified by the presence…The prevalence and characteristics of REM sleep behavior disorder in progressive supranuclear palsy patients.
Objective: To describe the prevalence and characteristics of RBD in patients diagnosed with PSP and to demonstrate the association with each PSP subtype. Background: Rapid…Baseline fluid biomarkers in a phase 2 clinical trial in Parkinson’s Disease
Objective: To evaluate baseline CSF and blood-based biomarkers of pathology in early-stage Parkinson’s Disease (PD) participants in the phase 2 clinical trial PASADENA. Background: Observational…
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