Innovating Clinical Trial Design to Accelerate Assessment of Disease-Modifying Treatments for Parkinson’s: The EJS ACT-PD Initiative
Objective: To design an optimal multi-arm, multi-stage (MAMS) platform trial for disease-modifying therapies (DMTs) in Parkinson’s disease (PD). Background: The current clinical trials process cannot…Age at Onset and Therapeutic Efficacy of Primidone in Essential Tremor Patients
Objective: To study the therapeutic response of primidone in different age groups of Essential Tremor (ET) patients, based on age at onset. Background: Essential Tremor…Design of a time-to-event study in GBA Parkinson’s Disease patients: Efficacy and safety of BIA 28-6156, an allosteric activator of beta-glucocerobridase (GCase)
Objective: To assess the efficacy of BIA 28-6156 in delaying clinically meaningful motor progression in PD patients who have a PD-risk associated variant in the…Speech difficulties and dopaminergic neurodegeneration in Parkinson’s Disease
Objective: To evaluate the association between speech difficulties and neurodegeneration of the putaminal dopaminergic system in people with early-stage treated with symptomatic therapy and advanced-stage…Disorder of bulk lipid transfer? Lipid composition and distribution in cellular models of VPS13A disease
Objective: To study the overall lipid composition and distribution in red blood cells (RBCs) and neurons derived from VPS13A disease patients, a neurodegenerative disorder associated…Screening and Treatment of Depression in Parkinson’s Disease Within Movement Disorders Centers
Objective: Implement depression screening using a validated instrument for people with Parkinson’s (PWP) as part of standard of care in the specialist movement disorders setting…Effects of Boxing and conventional physiotherapy techniques in patients with PD: A randomized control study
Objective: To determine the effectiveness of boxing vs. conventional physiotherapy techniques in improving the quality of movement, motor, cognitive functions in patients with PD. Background:…Hereditary spastic paraplegia type 4 (SPG4): an international multicenter clinical and genetic study
Objective: To describe the epidemiological, clinical, and genetic features of patients affected by hereditary spastic paraplegia (HSP) in an international cohort of affected individuals.To describe…A non-expensive bidimensional assessment can detect subtle alterations in gait performance in people in the early stages of Parkinson’s disease
Objective: To investigate the effectiveness of a two-dimensional gait assessment to identify the decline in gait performance associated with Parkinson's disease progression Background: Gait is…Prevalence of urinary symptoms and its impact on life quality in patients living with parkinson disease in a mexican population
Objective: To describe the prevalence and the impact on the quality of life in patients living with Parkinson’s disease with urinary symptoms. Background: Parkinson's disease…
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