Study protocol for the iMarkHD study in individuals with Huntington’s disease
Objective: To describe the study protocol for the iMarkHD study. Background: Huntington’s disease (HD) is still often defined by the onset of motor symptoms, inversely…Integrated safety analysis of BIA-28-6156 phase 1 clinical trials (a novel allosteric activator of beta-glucocerebrosidase)
Objective: To describe the safety profile and tolerability of BIA-28-6156 observed during phase 1 clinical trials. Background: BIA-28-6156 is a novel allosteric activator of beta-glucocerebrosidase…Microelectrode recording with subthalamic nuclei deep brain stimulation encompass neuro-electro physiological beta oscillations footmarks in Parkinson`s cardinal motor symptoms sub-types
Objective: To examine the behavioral-activity within sub bands of β-beta-oscillated local field potentials(‘LFP’) acquired through microelectrode recording(MER) from STN sub areas offer distinctive neuro-electro physiological…A Need for Improving the Diet Quality of Individuals with Parkinson’s Disease
Objective: This is a quality improvement project undertaken with an aim to evaluate the diet quality and adherence to the Mediterranean diet among individuals with…Movement disorders spectrum in CTNNB1-related neurodevelopmental disorders
Objective: To describe the phenomenology and clinical course of movement disorders in CTNNB1-related neurodevelopmental disorder (CTNNB1-NDD). Background: CTNNB1-NDD is a rare neurogenetic condition caused by…Dysphagia and dopaminergic neurodegeneration in Parkinson’s Disease
Objective: To evaluate the association between dysphagia and neurodegeneration of the putaminal dopaminergic system in people with early-stage treated with symptomatic therapy and advanced-stage Parkinson’s…Essential tremor suppression using a novel anti-tremor orthosis
Objective: Assess the efficacy of a novel anti-tremor orthosis in reducing hand and forearm tremor in patients with Essential Tremor in a clinical setting. Background:…Dynamic assessment of levels of depression and anxiety impairment in Parkinson’s disease
Objective: To dynamic assessment of depression and anxiety disorders in Parkinson's disease. Background: One of the most common nonmotor disturbances in Parkinson's disease (PD) is…Pareidolias and color discrimination deficits differently correlate with cognitive dysfunction in prodromal Lewy body disease
Objective: To investigate color discrimination ability and complex visual illusions known as pareidolias, and their associating factors in patients with iRBD compared to PD and…Caffeine Intake Interacts with Gene Variants in Parkinson’s disease
Objective: We investigate interactions of caffeine intake with PD risk variants and determine PD risk estimates in caffeine-drinkers carrying these variants. Background: Caffeine intake reduces…
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