modulation of sodium potassium ATPase activity by norepinepherine and serotonin to find an effective cure of parkinson’s disease by introducing the novel concept of insilico drug repurposing
Objective: Parkinson's disease can cause neuropsychiatric disturbances which can range from mild to severe. This includes disorders of speech, cognition, mood, behaviour, and thought. In addition to…Exercise and levodopa metabolism in Parkinson disease
Objective: The aim of our paper was to assess if standard physical exercise may change pharmacokinetics of levodopa/benserazide in patients with and without prior exposure…Tongue fasciculations and numbness: A case of calcifying pseudoneoplasm
Objective: To describe a 61-year-old female who presents with abnormal tongue movement found to have right frontoparietal calcifying pseudoneoplasm of the neuraxis (CAPNON). Background: CAPNON…Apathy, white-matter microstructure, and effort-based decision making in Parkinson’s Disease
Objective: To investigate the influence of reward and effort on behavior in PD patients with and without apathy, using a drift-diffusion model to analyze neuroimage…Multimodal imaging analysis of autosomal recessive Parkinson’s disease.
Objective: To explore whether autosomal recessive forms of monogenic PD (mPD) might lead to cortical and white matter (WM) abnormalities in addition to dopaminergic denervation.…Novel CACNA1A splice site variant associated with cerebellar ataxia and mild cognitive impairment; case report of Czech family.
Objective: To describe a case of two related individuals with cerebellar ataxia with a novel variant in the calcium voltage-gated channel subunit alpha1-A (CACNA1A) gene.…Prodromal stage early biomarkers in Parkinson’s disease and parkinsonism in Uzbek nationality
Objective: Evaluation of prodromal stage biomarkers in Parkinson's disease and their role in disease progression Background: From a pathophysiological point of view, PD is characterized…Development of potent, orally bioavailable, and highly selective LRRK2 PROTAC® degrader molecules as potential disease modifying therapeutics for Parkinson’s disease
Objective: Report on the pharmacological characteristics of small molecule PROteolysis TArgeting Chimera (PROTAC) molecules designed to induce degradation of leucine rich repeat kinase 2 (LRRK2)…Differential effect of MAPT haplotype on survival in CBD and PSP-SCB phenotype
Objective: Evaluate the association of MAPT haplotype with the risk of PSP-CBS and CBD severity of tau pathology by studying the survival rate of both…Measures of trancranial magnetic evoked potentials for prediction of response to ventriculoparitoneal shunt In normal pressure hydrocephalus
Objective: Assess the utility of an EEG-TMS-based evaluation for prediction of response to ventriculoperitoneal shunt (VPS) in normal pressure hydrocephalus (NPH). Background: VPS is the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.