Association of real-world wearable mobility measures with Parkinson’s disease severity and disease progression
Objective: To identify real-world mobility measures that are most reflective of PD severity and to assess their sensitivity to changes over time, as compared to…Training an APRN in movement disorders: lessons learned
Objective: To discuss the development and implementation of a training program of a neurology-naïve Advanced Practice Registered Nurse (APRN) into a small academic movement practice…Online recruitment and retention in the Parkinson’s Progression Markers Initiative (PPMI)
Objective: To describe participants and retention in the longitudinal PPMI Online cohort Background: The overall PPMI aim of biomarker identification to enable therapeutic development is…Understanding rehabilitation care utilization in Parkinson’s disease
Objective: The aim of our study was to examine experiences with rehabilitation services by people with Parkinson’s disease (PD) and their care partners (CP). Background:…Peripheral Synucleinopathy in Essential Tremor Plus Patients with Parkinsonian Features and Normal Dopamine Transporter Imaging
Objective: To describe results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) in patients with essential tremor (ET) with parkinsonism. Background: Patients with longstanding ET may…Impaired Mitophagy and Mitochondrial-energetics in Parkinson’s disease: A Novel Therapeutic Strategy of Re-tasking Felodipine
Objective: This study aimed to validate impairment of mitochondrial energetics and mitophagy in PD and the action of felodipine in restoring altered Mitochondria-lysosome (Mito-Lyso) homeostasis.…Membrane-associated properties and ER stress alterations in LRRK2 I1371V patient iPSC derived neurons increase susceptibility to oxidative stress.
Objective: To evaluate the pathophysiology of the midbrain dopaminergic neurons (mDAN) derived from LRRK2 I1371V PD patient-iPSCs leading to susceptibility to oxidative stress. Background: Studies…Development and quantified evaluation of a continuous smartphone app-based monitoring approach to individualize Parkinson’s disease management.
Objective: The aim of this study is the development and qualified evaluation of a smartphone app-based application to enable a longitudinal assessment of Parkinson’s disease…Insular dopamine deficits in prodromal α-synucleinopathies
Objective: aim of the study was to evaluate the dopamine binding characterizing subjects both at prodromal and symptomatic stages in α-synucleinopathies, by means of ROI-based…Short and long-term effects of deep brain stimulation on cognition in Parkinson’s disease
Objective: To evaluate long-term effects of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD) on cognition. Background: Cognitive changes are common among patients…
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