Inhibition of LRRK2 kinase activity promotes glucocerebrosidase transport to the lysosomes in primary monocyte-derived macrophages from patients with GBA-associated Parkinson’s disease
Objective: The aim was to evaluate the effectiveness of leucine-rich repeat kinase 2 (LRRK2) kinase activity inhibition in restoring transport of the enzyme glucocerebrosidase (GCase),…Identification of potential oxidative biomarkers in saliva of Parkinson’s disease patients
Objective: The goal of this study is to ascertain whether salivary oxidative markers are altered in Parkinson’s Disease (PD) and if there is an association of these markers with disease…Chorea following SARS-CoV-2 infection and vaccination: a systematic review
Objective: We aimed to investigate and compare data on chorea following SARS-CoV-2 infection and vaccination to provide an extensive perspective on this pathology and to…Evaluation of small extracellular vesicles derived miRNA as biomarkers for Parkinson’s disease: comparison with plasma miRNA
Objective: To identify differentially expressed small extracellular vesicles (sEV) derived miRNAs in Parkinson’s disease using small RNA-sequencing and to evaluate their potential as biomarker targets.…Computerized cognitive training in advanced Parkinson’s disease: preliminary feasibility data of an ongoing randomized controlled trial
Objective: To analyse the feasibility and effects on cognitive- and non-cognitive outcomes, and prediction of responsiveness of a computerized cognitive training (CT) in comparison to…Local field potentials in the subthalamic nucleus of patients with Parkinson’s disease – Effect of the deep brain stimulation
Objective: To obtain knowledge that would lead to the usage of local field potentials (LFP) in the deep brain stimulation therapy (DBS). Background: The LFP…Pain and quality of life in cervical dystonia
Objective: To evaluate different aspects of quality of life (QoL) and pain prevalence, characteristics and influencing factors in patients with cervical dystonia (CD) before and…Classification and genotype-phenotype relationships of GBA1 variants and Parkinson’s disease: MDSGene Systematic Review
Objective: To provide a comprehensive and systematic literature review of variants in the glucocerebrosidase 1 gene (GBA1) linked to Parkinson’s disease (PD). Background: Approximately 10% of patients with PD…Bone Health in Parkinson’s Disease
Objective: Optimise bone health in people with Parkinson’s Disease Background: People with Parkinson’s Disease (PD) have an increased risk of osteoporosis and associated fractures due…Late onset cerebellar ataxia in patients treated with VIM DBS
Objective: To highlight the predictors for onset of cerebellar ataxia in patients treated with deep brain stimulation (DBS) of the Thalamic Ventral Intermediate Nucleus (VIM)…
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