Visuo-spatial processing is linked to cortical glutamate dynamics in Parkinson’s disease – a 7 Tesla functional MRS study
Objective: To investigate alterations of glutamate metabolism in the occipital cortex during visual processing in patients with Parkinson’s disease (PD). Background: Cognitive decline is a…The changes in alpha-synuclein level and oscillatory activity of substantia nigra by nigral electrical stimulation
Objective: We aimed to clarify the relationships between the alpha-synuclein level and abnormal oscillatory activity and their changes induced by deep brain stimulation of the…Management of constipation in Parkinson’s patients presenting with acute sigmoid volvulus to Royal Berkshire Hospital,Reading, UK
Objective: To evaluate management of constipation in acute sigmoid volvulus in Parkinson’s. Background: Constipation is one of the main and disabling non motor symptoms in…Genome Wide Association Studies using TRACTOR reveals new associated loci with Parkinson Disease in a Latino Cohort
Objective: Our objective was using TRACTOR[1], which performs Genome Wide Association Study (GWAS) including Local Ancestry (LA) information, in Parkinson Disease (PD) using data from…Plasma glucosylsphingosine in GBA1 E326K, N370S and L444P mutation carriers with and without Parkinson’s disease
Objective: To measure plasma glucosylsphingosine levels in heterozygous carriers with and without Parkinson's disease (PD) of three variants in GBA1: 1. E326K (risk factor for…A validation study of the Mini-BESTest in a Spanish population with Parkinson’s disease.
Objective: Because the Mini Balance Evaluation Systems Test (Mini-BESTest) is widely used, our aim was to validate the Spanish version in PD. Background: Parkinson's disease…refractory myoclonus after COVID-19 with resolution after corticosteroids; a case report with brain biopsy and serial neuroimaging.
Objective: To present an individual with multifocal myoclonus after COVID-19 infection with resolution of bilateral MRI hyperintensities following corticosteroids use. Background: Myoclonus after Covid-19 infection…Hereditary spastic paraparesis due to SPG11 gene mutation presenting as dopa responsive dystonia
Objective: To describe a case of HSP presenting as spastic paraparesis with extrapyramidal features Background: Hereditary spastic paraparesis is a heterogeneous group of neurodegenerative disorders…3D-accelerometry characteristics of essential tremor and dystonic tremor
Objective: We aimed to characterize essential tremor and dystonic tremor using 3D accelerometry analysis. Background: Diagnosing essential tremor (ET) and dystonic tremor (DT) is often challenging.…Outcomes From Genetic Testing in a UK Movement Disorder Clinic
Objective: The reported yield from next generation sequencing (NGS) in Movement Disorder clinics is 11.3 – 22% [1,2]. We aimed to determine current practice and yield…
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