The comparison of curcumin and naringenin effects on motor function in rotenone model of Parkinson’s disease
Objective: The aim of the study was to compare the effects of curcumin and naringenin on rotenone-induced motor deficits and related neurochemical changes. Background: Experimental…LRRK2 kinase activity regulates sphingolipid hydrolase enzymatic activities in different cell lines: induced pluripotent stem cell-derived dopaminergic neurons, primary monocyte‐derived macrophages and SH-SY5Y
Objective: To assess whether inhibition of the kinase activity of LRRK2 affects changes in enzyme activity of sphingolipid hydrolase in the culture of dopaminergic neurons…The induction of mitochondrial damage by alpha synuclein In Parkinson’s disease.
Objective: Alpha synuclein aggregation have been indicted in the process of neuronal cell loss in Parkinson's disease; however, there have been several hypothesis to explain…Increased free water in the putamen in idiopathic REM sleep behaviour disorder
Objective: This study aimed to evaluate the free water in the dorsoposterior putamen of idiopathic REM sleep behaviour disorder (iRBD) patients, which is considered a…Artificial Intelligence to detect and classify tremors in patients with Parkinson’s disease and related conditions
Objective: To develop a machine learning program to detect and classify tremors in patients with Parkinson's disease (PD) and related conditions. Background: PD is the…FRMD5 de novo variants in two cases with childhood onset ataxia and seizures
Objective: To describe two cases affected by childhood onset ataxia and seizures carrying de novo variants in the gene FRMD5 Background: FRMD5 belongs to the…Defining neuropsychiatric symptoms fluctuations in Parkinson’s disease
Objective: To evaluate the demographic and clinical correlates of Parkinson’s disease (PD) patients with fluctuations of neuropsychiatric symptoms (NPS-F). Background: Clinical correlates of fluctuations of…Moving beyond trial and error: a strategy for anatomically informed contact selection in subthalamic deep brain stimulation for Parkinson’s disease.
Objective: In this study we aimed to investigate and compare the utility of conventional DBS programming strategies and anatomically informed approaches predicting long term motor…Utilization pattern and factors associated with amantadine use in Parkinson’s disease (PD) of the French NS-Park cohort
Objective: To assess amantadine use in the French NS-Park cohort and factors associated with its prescription Background: Amantadine, a unique dopamine/glutamate drug, is approved worldwide…Effects and neural mechanisms of training involving rhythmic auditory stimulation on upper-limb movements in patients with Parkinson’s disease
Objective: This study is to examine effects and neural mechanisms of training involving rhythmic auditory stimulation on upper-limb movements in patients with Parkinson’s disease (PD).…
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