BBP-671, AN INVESTIGATIONAL MODULATOR OF PANTOTHENATE KINASES, DEMONSTRATES PROOF OF CONCEPT IN A PKAN MOUSE MODEL AND TARGET ENGAGEMENT IN HUMANS
Objective: Efficacy of BBP-671 as a potential therapy for pantothenate kinase-associated neurodegeneration (PKAN) was evaluated in a PKAN mouse model. Safety, PK, and PD of…Targeted training improves touchscreen skills in Parkinson’s disease and healthy elderly
Objective: To investigate the effects of dual (DT) versus single task (ST) training of touchscreen skills in Parkinson’s disease patients (PD) and healthy elderly (HE).…Huntington’s Disease, Cognition, and Fear of Falling
Objective: Explore the relationship of cognition and patient-reported assessment on fear of falling in people with Huntington’s Disease. Background: Huntington’s Disease (HD) is a relentlessly…Ocular ping pong movement to disentangle apathy from Bradykinesia in Parkinson’s disease
Objective: To disentangle bradykinesia from apathy through analysis of ocular movements. Background: While Parkinson's disease (PD) is mainly characterized by motor symptoms such as bradykinesia,…Evaluation of ocular perfusion in Parkinson’s disease and association with clinical manifestations.
Objective: To evaluate optic nerve head and macular perfusion in subjects with Parkinson's disease (PD) and its association with clinical manifestations. Background: PD is associated…Five for the price of one- A multidirectional micro-electrode recordings for DBS Surgery
Objective: To examine the use of a multidirectional micro electrode during Deep Brain Stimulation (DBS) surgery for Parkinson's Disease (PD) in 9 patients. Background: Micro-Electrode…Validation of the English version of the Parkinson Anxiety Scale in the Canadian population: Interim results
Objective: To validate the use of the English version of the PAS in Parkinson’s disease (PD) patients in Canada. Background: The PAS, originally developed to…Clinicopathologic features of corticobasal syndrome associated with corticobasal degeneration, progressive supranuclear palsy, Alzheimer’s disease, and FTLD-TDP
Objective: To compare the clinicopathologic features of corticobasal syndrome (CBS) associated with corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Alzheimer's disease (AD), and frontotemporal lobar…High frequency neck vibration changes the pallidal activity in cervical dystonia
Objective: The aim of the current study is to characterize changes in spontaneous pallidal neuronal activity during modulation of peripheral proprioceptive input by means of…Virtual Visit Experience of the Portland Oregon Pacific UDALL Center During COVID-19
Objective: To retain a well-characterized longitudinal Parkinson’s Study, The Portland Oregon Pacific UDALL Center (PRE-PUC) cohort, during the pandemic years. Background: Although best known for…
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