Neuroanatomical underpinnings of apathy in Parkinson’s Disease
Objective: To investigated the integrity of white matter tracts within basal ganglia-frontal networks in PD patients with and without apathy, and relate these to specific…The mGlu2 positive allosteric modulator BINA extends enhances low dose L-DOPA anti-parkinsonian action in the MPTP-lesioned marmoset
Objective: To determine the effect of positive allosteric modulation of the metabotropic glutamate type 2 (mGlu2) receptor in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset using a low…Botulinum Toxin Therapy for Medication and DBS Refractory Foot Dystonia of Parkinsonism
Objective: To determine efficacy and safety of BTX therapy in patients with medically refractory foot dystonia secondary to Parkinson’s disease (PD) or atypical Parkinsonism (AP)…A Patient-Centered Outcomes Survey in Parkinson’s Disease: Results of Cognitive Pre-Testing
Objective: To validate the Rush Parkinson's Disease Patient-Centered Outcomes Questionnaire (RUSH-PCO-Q). Background: The RUSH-PCO-Q aims to address the lack of patient-centered outcomes in the field…Associations between stimulation-induced gamma entrainment and motor signs of Parkinson’s Disease
Objective: To determine whether entrainment of endogenous cortical gamma oscillations in patients with Parkinson’s Disease during deep brain stimulation is associated with improved motor fluctuations.…Predictors of relapse in impulse control disorders in patients with Parkinson’s disease.
Objective: Identify predictors of relapse in impulse control disorders (ICD) in patients with Parkinson's disease. Background: Behaviors that are performed repeatedly, excessively or minimally and…Lack of Toll-like receptor 4 is associated with accumulation of alpha-synuclein in the midbrain Parkinson’s disease mice.
Objective: In this study we aimed to investigate the potential role of Toll-like receptor 4 (TLR4) in mediating both the dopaminergic neuron loss and alpha-synuclein (alpha-SYN)…MRI to investigate cerebrovascular changes in Parkinson’s disease
Objective: To determine the value of MRI-derived cerebrovascular metrics and their relationship with global cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment is a…Postural tremors due to a cystic thalamic low-grade glioma treated by stereotactic aspiration
Objective: To describe a rare case of contralateral postural tremors of the upper extremity as the only presenting complaint due to a thalamic solid cystic…Characterization of gastrointestinal dysfunction in Parkinson’s by disease stage
Objective: To conduct a comprehensive cross-sectional and longitudinal characterization of gastrointestinal dysfunction (GID) in Parkinson’s disease (PD). Background: GID is an important feature of PD…
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