DBS Targeting in a Neuromodulation Monitoring Unit – First 30 cases
Objective: We evaluate potential targets for Deep Brain Stimulation (DBS) based on test stimulation and chronic recording from temporary depth electrodes placed in a Neuromodulation Monitoring…A progress update on the Critical Path for Parkinson’s consortium’s pre-competitive 3DT initiative
Objective: To provide a progress update on the Critical Path for Parkinson’s (CPP) consortium’s “Digital Drug Development” (3DT) initiative, which was established in 2019 with…Prospective, Multicenter, International Registry of Deep Brain Stimulation for Essential Tremor
Objective: This is a new Essential Tremor (ET) patient registry for patients implanted with a multiple-source, constant-current DBS system capable of providing directionality for use…Short and long-term cental action of botulinum neurotoxin treatment in laryngeal dystonia
Objective: To investigate short- and long-term central effects of BoNT treatment on brain function in patients with laryngeal dystonia (LD). Background: LD is an isolated…Effect of rehabilitation interventions on freezing of gait in people with Parkinson’s disease: a systematic review and meta-analyses
Objective: To summarize the effects of rehabilitation interventions to reduce freezing of gait (FOG) in people with Parkinson’s disease (PwPD). Background: FOG is a debilitating…Chronic administration of bitopertin, a GlyT1 inhibitor, in the dyskinetic 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To evaluate if, upon chronic administration, tolerance to the anti-dyskinetic effect of the glycine transporter 1 (GlyT1) inhibitor bitopertin, would develop, in the 6-hydroxydopamine…Status Update of EPSILON: a Phase III, Randomised, Placebo-Controlled Study of Opicapone in Early Parkinson’s Disease
Objective: This study aims to explore the potential of once-daily opicapone (OPC) 50 mg to enhance the clinical benefit of levodopa (L-dopa)/dopa decarboxylase inhibitor (DDCi)…Neuroimaging correlates of cognitive deficits in Wilson’s disease
Objective: To determine the anatomical basis for cognitive deficits in WD. Background: Cognitive impairment is common in neurological presentations of Wilson’s disease (WD).1 Various cognitive domains…Mania induced by STN-DBS is related to the stimulation of the ventromedial subthalamic nucleus in Parkinson’s disease: a prospective study
Objective: To investigate the incidence, risk and etiological factors, clinical management and consequences of mania following subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease…Quantitative susceptibility mapping of basal ganglia and related structures: correlation with disease severity in Progressive Supranuclear Palsy
Objective: We examined whether magnetic susceptibility estimates from deep gray matter structures in patients with Progressive Supranuclear Palsy (PSP) correlated with clinical measures of disease…
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