A Retrospective Case Review of Movement Disorder Video Case Conference ~ A 20-year Collaboration Between The Queen’s Medical Center in Hawai`i and University of Virginia
Objective: To review the cases seen at Movement Disorder Video Case Conference between The Queen's Medical Center and University of Virginia. Background: In 2001, The…A Case series of Hemichorea Hemiballism Associated with Non-ketotic Hyperglycemia and Unique Imaging findings
Objective: To avoid missed diagnosis of non-ketotic hyperglycemic hemichorea hemiballismus by discussing the phenomenology, radiological findings and therapy through this case series. Background: Hemichorea–hemiballismus associated…Demographics and Clinical Characteristics of Autosomal Dominant Spinocerebellar Ataxia in Canada: A Multicenter Study
Objective: To describe the demographics and clinical characteristics of Autosomal Dominant (AD) Spinocerebellar Ataxias (SCA) in the Canadian population. Background: SCAs are a group of…Altered visual network dynamics associated with freezing of gait in Parkinson’s disease
Objective: We aimed to characterize the dynamic functional connectivity (DFC) in people with FOG based on high temporal-resolution functional MRI (fMRI). Background: Freezing of gait…The key is “any movement”: results from a Cochrane systematic review and network meta-analysis on physical interventions for Parkinson´s disease
Objective: To compare the efficacy and safety of physical interventions for people with Parkinson's disease (PD). Background: Physical interventions are effective in managing PD, but…Bis(monoacylglycerol) phosphate levels are elevated at baseline in carriers of pathogenic variants in LRRK2 and GBA1 and do not predict progression of PD in PPMI cohorts
Objective: To assess: (a) effects of LRRK2 and GBA1 pathogenic variants on baseline urinary bis(monoacylglycerol) phosphate (BMP) levels in those with and without Parkinson’s disease…Factors associated with progression of Parkinson’s disease and deterioration in quality of life: Results of J-FIRST, a 1-year observational study
Objective: To investigate whether individual non-motor symptoms (NMSs) are associated with overall NMS or quality of life (QOL) in Parkinson's disease (PD). Background: Worsening motor…Catatonic Syndrome in Covid-19 Infection: Medication Treatment or Hyperbaric Oxygen Therapy.
Objective: Catatonic syndrome, or catatonia (from other Greek κατατείνω - “stretch, strain”), is a psychopathological syndrome (a group of symptoms), the main clinical manifestation of…Prevalence and distribution of disease-associated alpha-synuclein in a homeless population
Objective: To study the prevalence and distribution of pathological alpha-synuclein deposition, throughout the central and peripheral nervous systems, in a homeless population. Background: The homeless…Vodobatinib, a potent, orally bioavailable brain-penetrating inhibitor of c-Abl as a potential neuroprotective agent for the treatment of Parkinson’s Disease
Objective: To compare and contrast nilotinib and vodobatinib regarding efficacy, brain penetration, and safety. Background: Preclinical evidence suggests that c-Abl is critical for pathogenesis of…
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