Multimodal mechanistic disease stratification in sporadic Parkinson’s disease
Objective: To mechanistically stratify Parkinson’s disease (PD), applying a combination of putaminal 31Phosphorus magnetic resonance spectroscopy (31P-MRS) with detailed assessment of mitochondrial and lysosomal function…Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration
Objective: This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in frontotemporal lobar degeneration (FTLD). Background: Defective…KMT2B episignature analysis identifies a probably hypomorphic missense variant in a family with dystonic and non-dystonic phenotypes
Objective: Recently, DNA methylation episignature analysis has been introduced as a tool enabling re-classification of “variants of uncertain significance“ (VUS) in lysine-specific methyltransferase 2B (KMT2B),…Preliminary data on multimodal approach for early characterization of Parkinson’s disease (PD) and Multiple System Atrophy (MSA), a prospective study with connected insoles
Objective: Early analysis to evaluate changes in gait parameters as assessed on standardized and ecological conditions and their association to markers of disease progression, i.e.,…The benefit of exclusive nocturnal administration of a levodopa-carbidopa intestinal infusion for severe refractory sleep behavior disorder in Parkinson’s disease
Objective: Treatment by continuous diurnal intestinal infusion of levodopa is effective in improving sleep quality in Parkinson's disease (PD), but its use exclusively at night…Risk of Long-term Care Admissions Among Medicare Patients Treated with Pimavanserin or Other Atypical Antipsychotics for Parkinson’s Disease Psychosis
Objective: To examine all-cause long-term care (LTC) admission risk among PDP patients treated with atypical antipsychotic (AAP). Background: Risk of LTC-admissions associated with off-label AAPs…Illusion of semi-inverted posture during High Frequency Ultrasound Stimulation thalamotomy for tremor
Objective: In this study, we focused on the transient sensation of being tilted along the vertical axis during MRI-guided focused ultrasound (MRgFUS) for tremor. We…Detection of Parkinson’s Disease by Analysis of Smooth Pursuit Eye Movements and Machine Learning
Objective: The present study investigates an automatic method to parameterize smooth pursuit eye movements (SPEM) and to differentiate Parkinson's disease (PD) from controls using machine…Heterozygous mutations in the Parkin gene – two different presentations of Parkinson’s disease
Objective: The main objective of this work is to present two Parkinson's disease (PD) patients with heterozygous mutations in the Parkin gene (PARK – parkin)…Non-dopaminergic system is related with motor reserve in Parkinson’s disease
Objective: To find related brain structures with the motor reserve in Parkinson's disease (PD). Background: There is a discrepancy between the severity of parkinsonism and dopaminergic…
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