Autonomic Nervous System Dysfunction in idiopathic REM sleep behaviour disorder
Objective: To characterise autonomic impairment in REM sleep behaviour disorders, and to investigate the pathophysiological link between autonomic impairment and REM sleep behaviour disorder Background:…Longitudinal combined 11C UCB J and 18F FE PE2I PET imaging of presynaptic terminal loss in early Parkinson’s disease.
Objective: To longitudinally assess presynaptic terminal loss in vivo over a 2-year period in people with early Parkinson’s disease (PD). Background: Imaging tools that allow…Long-Term Neuropsychological Outcomes of Deep Brain Stimulation in Early-Stage Parkinson’s Disease
Objective: To report long-term (5-year and 11-year) neuropsychological outcomes from the deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot clinical trial. Background: The…Updated Parkinson’s disease motor subtypes classification and correlation to CSF HVA and 5-HIAA levels
Objective: To update a motor subtypes classification using the MDS-UPDRS and determine if CSF neurotransmitter profiles (HVA and 5-HIAA) are different between MDS-UPDRS subtypes in…Functional MRI and gait analysis characteristics in patients with idiopathic rem sleep behavior disorder
Objective: The aims of this study were to assess gait analysis, neurological, neuropsychological and resting-state functional MRI (RS-fMRI) functional connectivity (FC) characteristics in iRBD patients…Longitudinal clinical and biomarkers characteristics of non-manifest LRRK2 G2019S carriers: The PPMI cohort
Objective: To examine 2-year longitudinal change in clinical, dopamine transporter (DAT) imaging and biofluid biomarkers in non-manifesting carriers (NMCs) of LRRK2 G2019S versus healthy controls…Longitudinal study of Parkinson’s disease-related pattern with resting state functional MRI
Objective: To validate the previously characterized resting-state fMRI (rs-fMRI) Parkinson’s disease (PD)-related pattern, termed fPDRP, in a large multi-site PD imaging database, and to assess…P2B001 in the management of untreated PD. Results from a randomized, double-blind, double-dummy controlled trial
Objective: Evaluate the efficacy and safety of P2B001 compared with its components and with Extended-Release pramipexole (ER-PPX, calibration arm) in untreated PD. Background: P2B001 is…Postural Instability in Parkinson’s Disease: Phenotypic data from The Cincinnati Cohort Biomarker Program
Objective: To estimate the onset of postural instability in a cohort of Parkinson's disease (PD) patients. Background: The Cincinnati Cohort Biomarker Program (CCBP), launched in…Caregiving patients with Parkinson disease treated with deep brain stimulation: a systematic review and meta-synthesis of qualitative research
Objective: To explore the experiences and unmet needs of Parkinson disease patients (PDPs) caregivers after subthalamic nucleus deep brain stimulation (STN-DBS) by performing a systematic…
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