Gait ataxia and Autonomic dysfunction as early signs of Creutzfeldt-Jakob Disease: A Case Report
Objective: To highlight unusual early presenting symptoms of Sporadic Creutzfeldt-Jakob Disease (sCJD). Background: Prion diseases, a group of rare and fatal diseases caused by an…HAB-C murine model present reactive adult neurogenesis and astrogliosis in adult brain
Objective: To analyze the adult neurogenic response to a neurodegenerative process due to H-ABC tubulinopathy. Background: H-ABC is a neurodegenerative disease caused by mutations in…4 YEARLONG POST PARTUM AUTOIMMUNE CHOREA AS INITIAL PRESENTATION OF INCOMPLETE SLE/APS
Objective: The aim is to report a case of a 4 yearlong postpartum autoimmune chorea secondary to incomplete SLE/APS. Background: Chorea is a movement disorder…Mutational effects of LRRK2 I1371V in astrocytes derived from patient specific iPSCs
Objective: To identify the LRRK2 I1371V mutational effects on astroglial biology involving glutamate metabolism and glutathione machinery. Background: The underlying cause of most of the familial…DBS Experience In A Pediatric Neurowilson Case
Objective: I have chosen this case to demonstrate an atypical presentation of Neuro-Wilson disease without a prominent hepatic involvement. I have also aimed to call…Bullous skin lesions following introduction of safinamide in a woman with Parkinson’s disease
Objective: To present the case of a woman with Parkinson’s disease (PD) who developed pemphigoid-like skin lesions after being started on safinamide therapy. Background: Safinamide…Cognitive and Functional Trajectories in Prediagnostic Parkinson’s Disease
Objective: To describe prediagnostic cognitive and functional trajectories in Parkinson’s Disease (PD). Background: Cognitive and functional decline is typically considered a late manifestation of PD.…Blaming neuromelanin for Parkinson’s disease: time-dependent tyrosinase overexpression drives endogenous synucleinopathy in non-human primates
Objective: Development and characterization of a novel non-human primate model of Parkinson’s disease based on the AAV-mediated forced expression of human tyrosinase Background: Although neuromelanin…Quantity detection of Substantia nigra hyperechogenicity based on digital image analysis for diagnosing Parkinson’s disease
Objective: We aimed to apply digital analysis to quantify hyperechogenicity of Substantia nigra, and explore its clinical value for the diagnosis of PD. Background: Increased…Multimodal MRI assessment of the substantia nigra in premotor and motor stages of parkinsonism
Objective: To investigate substantia nigra (SN) MRI abnormalities through Neuromelanin (NM) and diffusion MRI (dMRI) with Neurite Orientation Dispersion and Density Index (NODDI) in the…
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