Preclinical characterization of UCB0022, an oral, brain penetrant, selective, clinical-stage positive allosteric modulator of the dopamine 1 receptor (D1 PAM)
Objective: To characterize the in vitro and in vivo pharmacologic profile of UCB0022 Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease with reductions in…Deep Brain Stimulation in Parkinson’s disease: Challenges of a young experience in southern Morocco
Objective: The objective of our research was to describe the epidemiological, therapeutic features and effectiveness of deep brain stimulation in operated patients. To cite the…CSF biomarkers in neurodegenerative parkinsonism can distinguish between multiple system atrophy and 4-repeat tauopathies, but not between disease with Lewy bodies and multiple system atrophy
Objective: To assess the usefulness of a defined set of blood-based and cerebrospinal fluid-based biomarkers in the differential diagnosis of neurodegenerative proteinopathies. Background: The diagnostic…An AAV9 encoding human ABCD1 (SBT101) shows functional improvement following spinal cord delivery in a rodent model of adrenomyeloneuropathy
Objective: SBT101 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy candidate delivering a functional copy of the human ABCD1 gene that is in development…The noradrenergic basis of Parkinson’s tremor
Objective: Study the effect of propranolol on (stress-related increase in) tremor power and on tremor-related activity in the cerebello-thalamo-cortical (CTC) circuit in Parkinson’s (PD) patients.…Attending to Compensatory Strategies during Prolonged Walking in Parkinson Disease: A Pilot Study
Objective: 1. to compare the effects of compensatory strategies on the duration of attentive engagement during 10 min. walking, 2. to test associations between person's…Multi-modal prognostic biomarkers for Parkinson’s disease progression and severity
Objective: To determine a pathophysiological panel of biomarkers significantly associated with the severity and the disease progression of Parkinson’s disease. Background: Detecting, monitoring and predicting…Anthropometric Changes in Parkinson’s Disease: Canadian Longitudinal Study on Aging
Objective: To explore the predictive role of anthropometric changes and development of Parkinson’s Disease (PD). Background: There is a tendency to lose weight in PD,…Apomorphine Hydrochloride Injection Treatment Initiations in the Presence and Absence of an Antiemetic in People with Parkinson Disease
Objective: To provide real-world experience regarding apomorphine treatment initiations with or without concomitant antiemetic prophylaxis. Background: Apomorphine hydrochloride (apo) injection, administered subcutaneously, is an “on-demand’…Worse Sleep Quality Aggravates the Motor and Non-Motor Symptoms in Parkinson’s Disease
Objective: The current study aims to investigate the association of sleep characteristics with motor and non-motor dysfunctions of Parkinson’s disease (PD) in a single-center, observational,…
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