Mitochondrial and autophagy alteration in a new fatty acid hydroxylase-associated neurodegeneration (FAHN) model
Objective: Establishing a FAHN Drosophila model to identify cellular disease mechanisms. Background: Fatty acid hydroxylase-associated neurodegeneration (FAHN) is an early-onset neurodegenerative disease that manifests brain…To Prescribe or Not to Prescribe: Assessing the impact of Parkinson’s nurse prescribers
Objective: Within the UK, after successful completion of a formally recognised programme Parkinson’s Nurse Specialists (PNS) can act as independent prescribers, and as part of…Isolated craniocervical dystonia without neuropsychiatric manifestations associated with NMDA-receptor antibodies
Objective: N-methyl-D-aspartate receptor (NMDAR) encephalitis classically spans neuropsychiatric disturbance, autonomic dysfunction and salient movement disorders. Attenuated presentations are increasingly recognised; however, presentations with an isolated…Pallidal firing rate and alpha oscillations correlate with the severity of clinical symptoms in patients with dystonia
Objective: To examined how pallidal activity correlates with symptom severity across dystonic patients. Background: The internal segment of globus pallidus (GPi) is the most common…Clinical Manifestations of Autonomic Dysfunction in Parkinsonism Assessed by COMPASS-31 Questionnaire
Objective: The study aims to describe the manifestations of autonomic disorders, including symptoms and related factors, in Parkinsonism cases Background: Parkinsonism is a progressive neurodegenerative…Autonomic dysfunction in p.A53T SNCA PD vs GBA PD and idiopathic PD : A study in a Greek population.
Objective: Τo assess whether autonomic dysfunction occurs in p.A53T SNCA mutation carriers manifesting Parkinson’s Disease (A53T-PD), using both subjective and objective measures and to compare…Altered Brain Connectivity in Hyperkinetic Movement Disorders: Systematic Review of Resting-State fMRI Studies
Objective: Providing a comprehensive literature review of resting-state brain connectivity alterations using resting-state fMRI (rs-fMRI) in hyperkinetic movement disorders (HMD). We additionally discuss alterations from…The reasons for referral to a Parkinson’s Clinical Psychology service
Objective: To understand the reasons for referral to a Parkinson's Clinical Psychology service. Background: In recent times, the psychological impact of Parkinson’s Disease has become…Reported Clinical and Quality-of-Life Outcomes With 24-Hour Levodopa-Carbidopa Intestinal Gel Administration Compared With 16-Hour Administration
Objective: To evaluate any existing differences between the reported outcomes in patients with advanced Parkinson’s disease (APD) using continuous 16-hour (hr) infusions of levodopa-carbidopa intestinal…Apomorphine Sublingual Film Versus Subcutaneous Apomorphine in the Treatment of OFF Episodes in Parkinson’s Disease: Results From an Assessment of Patient Satisfaction
Objective: Evaluate treatment satisfaction with apomorphine sublingual film (SL-APO) vs subcutaneous apomorphine (SC-APO) for the treatment of OFF episodes in patients with Parkinson’s disease (PD).…
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