Blood-derived α-synuclein from Parkinson´s disease patients is able to seed pathology
Objective: To identify seeding capacities of soluble α-synuclein (α-syn) conformers derived from neuronal extracellular vesicles (NEs) from Parkinson´s disease (PD) patients. Background: PD pathology is…Developing New Insights Into Clinical and Genetic Features of PD – The Global Parkinson’s Genetics Program (GP2) Clinical Cohorts Working Group
Objective: We aim to recruit Parkinson’s cohorts across the world for the Global Parkinson’s Genetics Program (GP2, http://gp2.org/), harmonize clinical data for joint analysis and…Effect of wearing knee braces on unsteadiness on standing in a case with primary orthostatic tremor
Objective: To clarify the effect of wearing knee braces (KB) on unsteadiness on standing in a case with primary orthostatic tremor (OT) using stabilometry and…Neurophysiological and Clinical Effects of Low-intensity Transcranial Ultrasound of the Motor Cortex in Parkinson’s Disease
Objective: Evaluate the neurophysiological and clinical effects of transcranial ultrasound stimulation (TUS) of motor cortex (M1) in PD patients. Background: Low-intensity TUS is a novel,…Cognitive profiles at presentation and subsequent cognitive decline in PD-MCI.
Objective: To determine cognitive profiles in a Parkinson‘s Disease-Mild Cognitive Impairment (PD-MCI) cohort, and study the relationship between baseline cognitive phenotype and subsequent cognitive decline.…Qualification of Digital Endpoints of Function in Healthy Volunteers for Use in a Decentralized Natural History Study in Genetic Parkinson’s Disease (PD)
Objective: Our goal was to qualify digital and wearable devices to assess the Timed Up and Go (TUG) test and gait related parameters in healthy…Correlation of Voice parameters and Dysphagia Severity in Multiple System Atrophy
Objective: To investigate the correlation between speech parameters and dysphagia severity in patients with MSA. Background: Dysphagia is an early and underestimated symptom in MSA…Explorative study of analysis of the role of NFL and IGF1 in Indian patients with PSP and its clinical correlation.
Objective: In this prospective cross sectional case control study, we have investigated the relationship of serum levels of Neurofilament light chain and Insulin like growth…Long-term follow-up of subthalamic nucleus deep brain stimulation for Parkinson’s disease: survival and disability milestones
Objective: To characterize retrospectively the long-term survival of 109 PD patients after 8 years of STN-DBS and to identify the incidence of the milestones of…Use of bupivacaine in the evaluation of acute secondary cervical dystonia (CD)
Objective: To highlight the potential use of bupivacaine/analgesics in assessing cervical dystonia, where disabling local pain can be a confounder and limits clinical examination. Background:…
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