Expanding the services of Neurogenetic Clinic – Lessons learnt from Cerebellar Ataxia cohort
Objective: We present an overview of patients seen by our Neurogenetic Clinic since 2019, focusing on the cerebellar ataxia (CA) cohort. Background: Diagnostic yield of…mGlu3 receptors in Parkinson’s disease as a candidate target for neuroprotective therapy: evidence from preclinical studies to human genetic.
Objective: In a toxicological model of mouse parkinsonism through chronic injection of MPTP, we examined whether the presence or absence of mGlu3 receptors affected neurodegeneration…Spinal cord stimulation for gait problems in Parkinson´s disease: Long term report and placebo viability
Objective: In the present study we set out to report a very long-term follow-up period of spinal cord stimulation (SCS) for Parkinson's Disease (PD) patients…Assessment of the long-term effects of STN-DBS on axial symptoms in PD patients through a standardized clinical-instrumental approach
Objective: To evaluate the long-term effects of bilateral STN-DBS and levodopa on axial symptoms in PD patients and the possible correlations between speech and gait…Dopamine neuron platform for screening molecular mechanisms and inhibitory drugs against alpha-synuclein aggregation
Objective: Optimization of a dopamine neuron based,in vitro platform is beneficial for studying molecular mechanisms of alpha-synuclein aggregation,and screening of inhibitory drugs and deducing their…The reliability and validity of the Ziegler test for measuring freezing of gait in people with Parkinson’s disease.
Objective: To determine the inter-rater and test-retest reliability of the Ziegler test to measure freezing of gait (FOG) severity in people with Parkinson’s disease (PwPD).…GPi-DBS induced brain metabolic activation in cervical dystonia
Objective: To investigate the effects of GPi-DBS on brain glucose metabolism locally at the stimulation site and across the whole brain in patients with cervical…Relationship between cholinergic basal forebrain volume and short-latency sensory afferent inhibition in Parkinson’s disease with varying degrees of cognitive performance
Objective: To assess the relationship between volumetric measures of cholinergic basal forebrain (CBF) degeneration and short-latency sensory afferent inhibition (SAI) in Parkinson’s disease (PD). Background:…Electrical stimulation of muscle afferents for tremor reduction in essential tremor patients
Objective: To describe the preliminary clinical results of a research project on electrical stimulation of muscle afferents to reduce tremor in patients with Essential Tremor…Impact of DBS on cognitive functions in Parkinson’s disease in 1 year follow-up
Objective: The aim of our study was to compare performance in neuropsychology tests in patients with Parkinson’s disease (PD) with implanted electrodes of Deep Brain…
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