Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework
Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…PP1α negatively regulates D2 receptor mediated cadmium induced motor dysfunctions: protective potential of Quercetin.
Objective: The present study has been focused to identify the molecular targets that involved in Cadmium-induced motor dysfunctions. At the same time, we also focused…Tracking longitudinal changes in MSA: TALISMAN study protocol
Objective: The European (EU) TALISMAN study will retrospectively and prospectively explore disease progression and the correlation with plasma neurofilament light chain (p-NfL) and brain MRI…Whole exome sequencing identifies novel variants underlying Ataxia with Oculomotor Apraxia type 1 in Pakistani consanguineous families
Objective: To investigate the underlying pathogenic variants in four consanguineous Pakistani families segregating Ataxia with Oculomotor Apraxia type 1 Background: Ataxia with Oculomotor Apraxia type 1…Changes in the level of glial neurotrophic factor in Parkinson’s disease depending on the form
Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) depending on the form Background: Neurotrophic factors…Deep Brain Stimulation in Woodhouse Sakati Syndrome:A Single Institution Retrospect Analysis
Objective: Evaluation of clinical response in patients with WSS-associated generalized dystonia following DBS to GPI Background: Woodhouse–Sakati syndrome (WSS) is a rare autosomal recessive disease,…Understanding the continuing educational needs of US clinicians managing OFF episodes in Parkinson’s disease
Objective: This study sought to understand the continuing medical education (CME) needs of US-practicing neurologists (NEUROs) and neurology advanced practice providers (APPs) in managing patients with Parkinson’s Disease (PD) experiencing…Association of a new pathogenic variant of LRRK2 with modifying lysosomal genes in a family with Parkinson’s disease
Objective: To characterize a Parkinson’s disease (PD) family with high recurrence of the disease. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder in which…Myelination relevant plasma microRNA biomarkers identified via an innovative data analytic scheme for differential diagnosis of MSA, an Oligodendroglial Synucleinopathy
Objective: To establish an inclusive data analytic scheme to identify and characterize plasma microRNA biomarkers with pathophysiological significance for differentiating the atypical Parkinsonian, Multiple System…Body Image Scale in Functional Movement Disorders; A Comparative Study
Objective: Objective: The aim of this study is to compare the BSI in patients with functional movement disorders and healthy volunteers. Background: Background: Functional movement…
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