Chronic administration of bitopertin, a GlyT1 inhibitor, in the dyskinetic 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To evaluate if, upon chronic administration, tolerance to the anti-dyskinetic effect of the glycine transporter 1 (GlyT1) inhibitor bitopertin, would develop, in the 6-hydroxydopamine…Levodopa Pharmacokinetics in Different Levodopa Treatment Regimens plus Opicapone in Parkinson’s Disease Patients with Motor Fluctuations
Objective: This study aims to evaluate the effect of once-daily opicapone (OPC) 50 mg on the pharmacokinetics (PK) of levodopa (LD) in different LD/carbidopa (LD/CD)…Relationship between gait speed and functional measurements in Parkinson’s disease
Objective: The present study aims to relate gait speed in Parkinson's disease (PD) with functional measures of muscle strength, balance and physical capacity. Background: PD…STN-DBS Targeting SNr Modulates Sleep in Parkinson’s Disease: A Proof-of-Concept Study
Objective: To explore how subthalamic deep brain stimulation (STN-DBS) targeting substantia nigra pars reticulata (SNr) can modulate sleep in Parkinson’s disease (PD) patients with electrophysiologic…Pseudodystonia due to Palmaris Brevis Syndrome: Case Report
Objective: We describe a case of pseudodystonia caused by palmaris brevis syndrome. Background: Palmaris brevis (PB) syndrome is a pseudodystonia characterized by spontaneous, involuntary, nonpainful…Mosaicism for somatic SNCA copy number variants in multiple system atrophy is related to pathological subtype and presence of α-synuclein inclusions
Objective: To investigate the correlation of somatic copy number variants (CNVs) of the alpha-synuclein gene (SNCA) in multiple system atrophy (MSA) with disease subtype, and…Assessment of non-motor symptoms of Parkinson’s disease in the long-term follow-up after the cell therapy
Objective: To evaluate the results of the introduction of MSCs on the non-motor symptoms in patients with PD within 12 months after the cell therapy.…A qualitative study exploring the treatment burden and capacity of people with Parkinson’s and their caregivers
Objective: To explore experiences of treatment burden and capacity in Parkinson’s and identify potentially modifiable factors that can improve this Background: Treatment burden, the workload…Volumetric analysis of the Corpus Callosum in Hereditary Cerebellar Ataxia
Objective: To analyze corpus callosum (CC) volumes on MRI in patients under follow-up for confirmed or suspected hereditary cerebellar ataxia Background: It is recognized that…Subclinical cognitive patterns of caudate-anchored connectivity in early Parkinson’s disease
Objective: This study is aimed at elucidating the changes of cognitive connectivity according to orthostatic stress in early Parkinson’s disease (PD). Background: 18F-Florbetaben tracer can…
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