Successful deep brain stimulation for bilateral Holmes tremor caused by progressive multifocal encephalopathy.
Objective: To report a unique case of a patient with acquired Holmes tremor (HT) secondary to Human Immunodeficiency Virus (HIV) and progressive multifocal leukoencephalopathy (PML)…Fatigue at different stages of parkinson’s disease
Objective: study fatigue as a key non-motor symptom of parkinson's disease Background: Fatigue in PD refers to a state of fatigue, lack of energy, a…Clinical and biomarker characteristics of Huntington’s Disease patients recently proposed for huntingtin-lowering clinical trial inclusion
Objective: We investigated plasma NfL levels, as well as clinical measures, in Huntingtin (Htt)-mutation carriers 48 years of age and under, with a CAP score…Pons and middle cerebellar peduncle diameters are diagnostic of Multiple System Atrophy of the Cerebellar Type (MSA-C)
Objective: To develop an MRI biomarker for the definitive diagnosis of Multiple System Atrophy of the Cerebellar Type (MSA-C). Background: MSA is a sporadic, adult-onset…Jumping the Gun Sign: a sign for “Waiting Impulsivity” of progressive supranuclear palsy
Objective: We presumed that the “jumping the gun sign (JGS)” is caused by an impairment of “waiting impulsivity” rather than “stopping impulsivity”, as seen on…Patient-specific multivariate gray matter volumetric distance to predict disease severity in Parkinson’s disease
Objective: Identifying novel biomarkers to predict disease progression is of paramount importance in patients with Parkinson’s disease (PD). In this study, we utilized Structural Magnetic…Structural MRI prediction of freezing of gait in Parkinson’s disease after deep brain stimulation
Objective: 1) To describe the evolution of FOG in a large cohort of patients at 1 year postoperatively from bilateral STN-DBS in PD. 2) To…Intermediate cardiac denervation in early Parkinson’s disease
Objective: This study is aimed to evaluate the longitudinal associations between cardiac sympathetic denervation and cognitive status in Parkinson’s disease (PD). Background: There lacks an…Developing zebrafish CRISPR/Cas9 knockout models of Parkinson’s Disease to identify novel therapeutic targets.
Objective: Human patients present punctual mutations and/or small deletions in genes that have been associated with Parkinson’s disease, namely, park1, park2, park6, park7, and park8.…Safety, Target Engagement and Effects of Bosutinib in Dementia with Lewy Bodies
Objective: To investigate the safety, biomarkers effects and determine the lowest effective dose of Bosutinibin Dementia with Lewy Bodies (DLB) Background: The effects of bosutinib,…
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