IkT-148009 as a potential disease-modifying therapy in PD
Objective: Modeling Parkinson’s disease in mice suggests c-Abl activation is required for PD initiation and progression, and therefore inhibition of c-Abl could be a strategy…Validation of a patient-reported functional mobility composite score (FMCS) in people with typical Parkinson’s disease
Objective: To investigate the convergent and discriminative validity of a patient-reported FMCS in people with typical PD (PwP). Background: Although a patient-reported instrument is less…Outcome measurement and goal setting recommendations in the multipattern treatment of shoulder spasticity with botulinum neurotoxin
Objective: To present expert consensus on choice of outcome measurement scales and goal setting recommendations for botulinum neurotoxin (BoNT) in the treatment of shoulder spasticity…The efficacy of Botulinum toxin A in reducing muscle spasticity by different volumes of dilution
Objective: Spasticity is a speed-dependent increase in muscle tone associated with stiffness, enhanced osteotendinous reflexes, paresis, loss of fine motor control, and increased fatigue. The…Cognitive dysfunction in cervical dystonia
Objective: To assess prevalence of anxiety and depression in patients with CD and investigate cognitive changes including social cognition and executive function. Background: Cervical dystonia,…The Genetic Landscape of Parkinson’s disease in populations of non-Caucasian ancestry.
Objective: We aimed to review existing literature on the genetic background of Parkinson’s disease (PD) populations of non-Caucasian or mixed ancestry. Background: There has been…Effect of Aspartame on Parkinson’s Disease Progression and Severity
Objective: The purpose of this review was to assess the current evidence regarding the effect of aspartame (APM) consumption on Parkinson’s Disease (PD) severity. Background:…Neuropathological profile of tauopathy in spinocerebellar ataxia type 8
Objective: The purpose of this study is to examine the distribution of tau pathology in brain regions of patients with spinocerebellar ataxia type 8 (SCA8).…Body-first and brain-first PD animal models mimic human PD subtypes
Objective: Here, we aim to model body- and brain-first PD by injecting pathology in the gut and amygdala of old wild-type rats, respectively. Background: Parkinson’s…Clinical and risk profiles of Parkinson’s disease from a large pan-India cohort: interim observations of the GAP-India study
Objective: To create a pan-Indian clinical repository of Parkinson’s Disease (PD). Background: The genetic risk for PD in India is unknown. The Luxembourg-German India Alliance…
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