Alterations in neuron-derived exosomal cargo in Parkinson Disease
Objective: The main objectives are 1) the confirmation of exosome isolation, based on iPSC-derived midbrain neuron model, 2) the identification of α-synuclein cargo of PD-patient…Gait under unsupervised, but not supervised conditions, differentiates between Parkinson disease with and without fatigue
Objective: To Assess the impact of fatigue on gait in Parkinson Disease patients in different evaluation conditions. Background: Fatigue is a common and disabling symptom…Subjective Self-Report on Sexual Problems in Parkinson’s disease is Reliable
Objective: To propose a practical, effective, and user-friendly tool for health care professionals to assess sexual problems among PwP. Background: Sexual dysfunction (SD) is a…Need for personalized monitoring in Parkinson’s disease: the perspectives of patients and specialized healthcare providers
Objective: To identify the motivations for and barriers against monitoring Parkinson’s disease (PD) symptoms among patients and healthcare providers, and to investigate which aspects of…Late Onset Hemichorea Of Vascular Origin In A Middle Aged Female With Recent Onset Diabetes
Objective: Late onset hemichorea in a diabetic patient could be either due to a vascular cause or Chorea Hyperglycemia Basal Ganglia Syndrome. The distinction between…Genetic stratification of motor and quality of life outcomes in Parkinson’s disease in the EARLYSTIM study
Objective: We identified (Weiss et al., 2016) that single nucleotide polymorphism (SNPs) of the alpha-synuclein gene (SNCA) predicted the motor effect of subthalamic nucleus stimulation (STN-DBS)…GLA-associated early-onset Parkinson’s disease: the mimicry between Fabry disease and parkinsonisms
Objective: To characterize an early-onset Parkinson’s disease (EOPD) patient with atypical clinical phenotype. Background: Genome sequencing is allowing new Parkinsonian Syndromes (PS)-associated genes identification. However,…Adults with slowly progressive dystonia-parkinsonism secondary to manganese accumulation
Objective: To expand the clinical spectrum of manganese-induced neurodegeneration. Background: Neurodegeneration induced by manganese accumulation is a potentially treatable condition and therefore should not be…Increased Neutrophil to Lymphocyte Ratio Distinguish Parkinson’s Disease and Parkinson Plus Syndrome
Objective: To investigate the peripheral inflammatory markers distinguishing Parkinson’s disease (PD) or Parkinson plus syndrome (PPS). Background: Previous studies had suggested that peripheral inflammation may…TWO-DIMENSIONAL SMOOTH PURSUIT TESTS FOR EARLY PARKINSON’S DISEASE IDENTIFICATION
Objective: To report qualitative analysis of smooth pursuit (SP) abnormalities found in early Parkinson´s disease (PD) patients using one- and two-dimensional test. Background: The eye…
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