Genetic stratification of motor and quality of life outcomes in Parkinson’s disease in the EARLYSTIM study
Objective: We identified (Weiss et al., 2016) that single nucleotide polymorphism (SNPs) of the alpha-synuclein gene (SNCA) predicted the motor effect of subthalamic nucleus stimulation (STN-DBS)…GLA-associated early-onset Parkinson’s disease: the mimicry between Fabry disease and parkinsonisms
Objective: To characterize an early-onset Parkinson’s disease (EOPD) patient with atypical clinical phenotype. Background: Genome sequencing is allowing new Parkinsonian Syndromes (PS)-associated genes identification. However,…Adults with slowly progressive dystonia-parkinsonism secondary to manganese accumulation
Objective: To expand the clinical spectrum of manganese-induced neurodegeneration. Background: Neurodegeneration induced by manganese accumulation is a potentially treatable condition and therefore should not be…Increased Neutrophil to Lymphocyte Ratio Distinguish Parkinson’s Disease and Parkinson Plus Syndrome
Objective: To investigate the peripheral inflammatory markers distinguishing Parkinson’s disease (PD) or Parkinson plus syndrome (PPS). Background: Previous studies had suggested that peripheral inflammation may…TWO-DIMENSIONAL SMOOTH PURSUIT TESTS FOR EARLY PARKINSON’S DISEASE IDENTIFICATION
Objective: To report qualitative analysis of smooth pursuit (SP) abnormalities found in early Parkinson´s disease (PD) patients using one- and two-dimensional test. Background: The eye…Improving the patient self-awareness of the first motor fluctuations in early Parkinson’s disease with a wearable sensor
Objective: We aim to assess if the use of a wearable sensor can increase the patient and caregiver self-awareness of the first motor fluctuations (MF).…IMPACT OF COVID 19 ON PARKINSON’S DISEASE: A CROSS SECTIONAL STUDY
Objective: To review the impact of Covid 19 on symptoms and signs of Parkinsons as well as general being in patients with Parkinson’s Disease at…Estimating the Meaningful Within-Patient Change Threshold for the MDS-UPDRS Part III
Objective: To estimate the meaningful within-patient worsening threshold (MWPWT) of the Movement Disorders Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS Part III in early-stage Parkinson's disease…Systematic Literature Review of Key Outcomes Used to Assess Adjunctive Treatments for Parkinson’s Disease
Objective: Understand key efficacy outcomes used to assess adjunctive treatments to carbidopa/levodopa (CD/LD) for Parkinson’s disease (PD). Background: CD/LD is widely considered the most effective…Clinical and electrophysiological validation of a volume of tissue activation model for directional deep brain stimulation leads – the ReCaps study
Objective: Assessing the predictive value of a volume of tissue activation (VTA) model for directional deep brain stimulation (DBS) leads on the response threshold of…
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