Defining minimal clinically important differences in Huntington’s disease: An anchor-based approach
Objective: This study aims to estimate the longitudinal minimal clinically important difference (MCID) for HD-relevant, cognitive, motor, and functional outcome measures. We used the new…MPTP-induced structural reorganization of neurons in mice Basal Ganglia: Verifying the sequelae of differential toxicity
Objective: To evaluate the changes in the neuronal arborization of the medium spiny neurons of striatum & substantia nigra neurons, in response to MPTP in…Caregiver’s burden in Parkinson’s disease: A mixed methods study
Objective: This study had a two-fold aim: (i) to assess how characteristics of informal caregivers and people with PD affect caregiver burden and (ii) to…Cortical Correlates of Gait in Pre-Manifest And Early Spinocerebellar Ataxia
Objective: We investigated whether prefrontal cortex activity is increased during walking in pre-manifest and early spinocerebellar ataxia (SCA) compared to healthy controls. Background: Spinocerebellar ataxia…It takes a village: An interdisciplinary care model for atypical Parkinsonism
Objective: To describe one interdisciplinary clinic designed to offer comprehensive care to patients with atypical parkinsonism syndromes, and to share the lessons learned which may…Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in enriched iPSC-derived human midbrain dopaminergic neurons
Objective: Develop and adapt a differentiation paradigm to produce enriched hiPSC-derived midbrain dopaminergic neurons (mDA), to resolve the temporal sequence of pathophysiological events in synucleinopathies.…Towards a Machine Learning Based Classification System for Hyperkinetic Movement Disorders: Generating a Neurophysiological Feature Set
Objective: Generating a set of significant neurophysiological features to build a machine learning based diagnostic system for hyperkinetic movement disorders. Background: Hyperkinetic movement disorders cause…Longitudinal study of clinical and neurophysiological features of essential tremor
Objective: This study investigates how motor and non-motor manifestations of essential tremor (ET) progress over time. Background: ET is a common and heterogeneous movement disorder…Clinical,imaging and genetic correlations in a Neuronal Brain Iron accumulation cohort from India
Objective: To correlate, clinical and magnetic resonance imaging (MRI) characteristics, of patients with neurodegeneration with brain iron accumulation (NBIA), with genetics and establish genotype-phenotype correlations…High preoperative gait variability is a prognostic predictor of gait and balance in Parkinson disease patients with deep brain stimulation
Objective: To elucidate the objective biomarker for long-term outcome of STN DBS in PD patients, we investigated the value of pre-operative quantitative gait parameters for…
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