Evaluation of α-synuclein pathology and function in dopaminergic neurons derived from LRRK2 I1371V PD patient iPSCs
Objective: To evaluate cellular pathogenesis in DA neuron function, and α-synuclein pathology using LRRK2-I1371V PD iPSC. Background: It is reported for complex-neurodegenerative disorders like PD,…Establishing and validating 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced zebrafish model of Parkinson’s disease
Objective: The current study aims to establish a zebrafish model of PD using MPTP neurotoxin and the validation of the MPTP effect through swimming behavior…Facial emotion recognition in Parkinson’s disease: the role of executive and affective domains
Objective: We aimed to explore facial emotion recognition (FER) skills in individuals with Parkinson’s disease (PD) by using a dynamic presentation of emotions across different…The prevalence of helicobacter pylori in Parkinson’s disease
Objective: to study the association between helicobacteriosis pylori (HP) and patients with Parkinson's disease Background: Helicobacter pylori is a bacterium associated with gastrointestinal diseases and…Mimics or multiplicity: two patients with a PSP phenotype and underlying genetic neurodegenerative disorders.
Objective: To describe a two cases of patients presenting with a PSP phenotype and genetic findings consisted with Huntington’s disease (HD) in one case and…Transcranial magnetic resonance-guided focused ultrasound in Lance-Adams syndrome
Objective: The objective is to present the first reported case of a patient with post-hypoxic myoclonus (PHM) who underwent noninvasive MR-guided Focused Ultrasound Treatment (MRgFUS).…A phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor: KINETIC 2 trial in progress
Objective: The phase 2b KINETIC 2 trial is a double-blind, randomized, placebo-controlled, dose-response study designed to evaluate SAGE-324/BIIB124 (SAGE-324) for the treatment of patients with…Smoking and Substantia Nigra Neuron Density in the Presence and Absence of Lewy Pathology
Objective: Our objective is to examine the association of mid-life smoking with post mortem substantia nigra (SN) neuron density in the presence and absence of…Assessment of novel diffusion MRI metrics of cortical microstructure in the genetic continuum of Parkinson’s disease
Objective: To investigate novel cortical diffusivity metrics in Parkinson’s disease (PD), including both prodromal and established genetic PD, alongside sporadic PD and healthy controls (HC).…Capturing the complexity of patients with parkinsonism: Baseline characteristics of participants in the PRIME-UK cross-sectional study
Objective: This cross-sectional study seeks to describe the symptomatology and health needs of a representative sample of people with parkinsonism, including those living with frailty,…
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