LY-487,379 alleviates parkinsonism when administered as monotherapy in the MPTP-lesioned marmoset
Objective: To determine the effect of selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulation as monotherapy on parkinsonism, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset. Background: We…LY-487,379 enhances the anti-parkinsonian action of a low dose of L-DOPA in the MPTP-lesioned marmoset
Objective: To investigate the effect of selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulation on the anti-parkinsonian action of a low dose of…Effect of simultaneous mGlu2 positive allosteric modulation and orthosteric stimulation combined with 5-HT2A antagonism on psychosis-like behaviours, dyskinesia and parkinsonism in the MPTP-lesioned marmoset
Objective: To assess the effects of concurrent metabotropic glutamate type 2 (mGlu2) positive allosteric modulation and orthosteric stimulation combined with serotonin type 2A (5-HT2A) antagonism.…Problems faced by Parkinson’s disease patients during COVID-19 pandemic compulsory lockdown and its management with the help of Telemedicine in a North Indian cohort
Objective: To study problems faced by PD patients during lockdown due lack of healthcare and medication procurement and address such problems using telemedicine via virtual…Comparison and analysis of pupillometer parameters between patients with drug naive Parkinson’s disease and controls
Objective: We compared the pupillary findings of drug-naïve Parkinson’s disease (PD) patients and controls to investigate the characteristics of pupillary light reflexes (PLR) in PD…Sexual dysfunction in female patients with Multiple System Atrophy
Objective: To characterize sexual dysfunction in female patients with Multiple System Atrophy (MSA). Background: The diagnosis of probable MSA relies on the presence of parkinsonian…A retrospective review of clinical features of Progressive Supranuclear Palsy (PSP) in a movement disorders clinic
Objective: Understanding the common clinical features of PSP. Background: PSP is a relatively rare progressive neurodegenerative disease, which can often be difficult to distinguish from…Coffee, smoking and aspirin are associated with age at onset and clinical severity in idiopathic Parkinson’s disease
Objective: To investigate a possible association between smoking, the consumption of caffeine and the use of aspirin on age at onset (AAO), motor and non-motor…Extensive volume increases sensitivity of alpha-synuclein accumulation in the gastrointestinal tract
Objective: This study aimed to verify whether evaluation of extensive tissue volume increases sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract in…Long-term cognitive and motor decline across the spectrum of Lewy body disease.
Objective: This study aims to compare the progression of motor and cognitive decline in dementia with Lewy bodies (DLB) compared with Parkinson’s disease (PD) using…
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